Trial · NCT02379637
Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough
NCT02379637, Phase 2, Completed, Novartis; results first posted 2016-07-11
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough. Trials, record NCT02379637. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02379637
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Study to Evaluate the Efficacy of N-acetylcysteine (NAC) in the Treatment of the Common Cold and Cough
- NCT number
- NCT02379637
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 70 participants, actual
- Lead sponsor
- Novartis
- Conditions
- Common Cold Associated With Cough
- Interventions
- N-acetylcysteine, Placebo
- First posted
- 2015-03-05
- Last updated
- 2016-07-11
- Results first posted
- 2016-07-11
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Cough Count (Number of Coughs Will be Measured by a 24-hour Ambulatory Cough Monitoring System for the First 72 Hours) | 72 hours | Number of coughs will be measured by a 24-hour ambulatory cough monitoring system for the first 72 hours |
| Secondary | Safety of Daily Dose of NAC (Number of Patients With Adverse Advents) | 7 Days | Number of patients with adverse advents |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Cough Count (Number of Coughs Will be Measured by a 24-hour Ambulatory Cough Monitoring System for the First 72 Hours) | 72 hours | Full Analysis set | log-transformed total cough count | MEAN |
| SECONDARY | Safety of Daily Dose of NAC (Number of Patients With Adverse Advents) | 7 Days | participants | NUMBER |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Cough Count (Number of Coughs Will be Measured by a 24-hour Ambulatory Cough Monitoring System for the First 72 Hours) | A N-acetylcysteine | 6.92 | Standard Deviation 0.95 | log-transformed total cough count | |
| Cough Count (Number of Coughs Will be Measured by a 24-hour Ambulatory Cough Monitoring System for the First 72 Hours) | B Placebo | 6.51 | Standard Deviation 0.83 | log-transformed total cough count | |
| Safety of Daily Dose of NAC (Number of Patients With Adverse Advents) | A N-acetylcysteine | 4 | participants | ||
| Safety of Daily Dose of NAC (Number of Patients With Adverse Advents) | B Placebo | 4 | participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | A N-acetylcysteine | 35 | |
| Overall Study | STARTED | B Placebo | 35 | |
| Overall Study | COMPLETED | A N-acetylcysteine | 33 | |
| Overall Study | COMPLETED | B Placebo | 34 | |
| Overall Study | NOT COMPLETED | A N-acetylcysteine | 2 | |
| Overall Study | NOT COMPLETED | B Placebo | 1 |
Source ClinicalTrials.gov
Adverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Dyspepsia | Gastrointestinal disorders | A N-acetylcysteine | 2 | 35 | 2 |
| other | Dyspepsia | Gastrointestinal disorders | B Placebo | 2 | 35 | 2 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | A N-acetylcysteine | ||
| Total, all-cause mortality | B Placebo | ||
| Total, other adverse events | A N-acetylcysteine | 2 | 35 |
| Total, other adverse events | B Placebo | 2 | 35 |
| Total, serious adverse events | A N-acetylcysteine | 0 | 35 |
| Total, serious adverse events | B Placebo | 0 | 35 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| A N-acetylcysteine vs B Placebo: Safety of Daily Dose of NAC (Number of Patients With Adverse Advents) | Trial comparisons |
| A N-acetylcysteine vs B Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02379637
GET https://conductscience.org/api/trials/v1/NCT02379637/registered