An Investigation Into the Effects of a Wild Blueberry Powder and a Wild Blueberry Extract on Cognition in Older Adults
NCT02446314, Not applicable, Completed, University of Reading; results first posted 2019-08-08
Trial 11
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | An Investigation Into the Effects of a Wild Blueberry Powder and a Wild Blueberry Extract on Cognition in Older Adults | ClinicalTrials.gov |
| NCT number | NCT02446314 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 122 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Reading | ClinicalTrials.gov |
| Conditions | Cognitive Decline | ClinicalTrials.gov |
| Interventions | Placebo, Wild Blueberry Powder - 450mg, Wild Blueberry Powder - 900 mg, Wild Blueberry extract 100mg | ClinicalTrials.gov |
| First posted | 2015-05-18 | ClinicalTrials.gov |
| Last updated | 2019-08-08 | ClinicalTrials.gov |
| Results first posted | 2019-08-08 | ClinicalTrials.gov |
Registered outcomes 10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Proportion of Words Correctly Recognised. | 12, and 24 weeks | Participants indicate whether words presented on a monitor are from a list of 15 words previously presented auditorily (via headphones), or if they are novel foils. | ClinicalTrials.gov |
| Primary | Total Number of Correct Sequences Recalled | 12, and 24 weeks | Participants view an array of 9 white squares on a monitor which light up red in sequences of between 2 and 9. They are then required to press the correct squares in the sequence they were presented. | ClinicalTrials.gov |
| Primary | Combined Z Score of Delayed Words Recalled, Words Recognised, and Pictures Recognised. | 12, and 24 weeks | Combined Z score of proportion of words recalled, proportion of words recognised, and proportion of pictures recognised. The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean. Negative numbers indicate values lower than the mean and positive numbers indicate values higher than the mean. A negative change value reflects a decrease in memory or a worse outcome and a positive change value reflects an increase in memory or a better outcome | ClinicalTrials.gov |
| Secondary | Combined Z Score of Mean Reaction Time Scores for Incongruent Attention Network and Stroop Task Trials. | 12, and 24 weeks | Combined Z Score of Mean Reaction Time Scores for Incongruent Attention Network and Stroop Task Trials. The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean. Negative numbers indicate values lower than the mean and positive numbers indicate values higher than the mean. A negative change value reflects a decrease in memory or a worse outcome and a positive change value reflects an increase in memory or a better outcome. | ClinicalTrials.gov |
| Secondary | Combined Z Score of Proportion of Immediate Words Recalled, Number of Correct Serial 3 and Serial 7 Subtractions, Sternberg Task Coefficent of the Line | 12, and 24 weeks | Combined Z Score of Proportion of Immediate Words Recalled, Number of Correct Serial 3 and Serial 7 Subtractions, and the Coefficient of the Line for Reaction Time by Length of Sting During Probe Recall. The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean. Negative numbers indicate values lower than the mean and positive numbers indicate values higher than the mean. A negative change value reflects a decrease in memory or a worse outcome and a positive change value reflects an increase in memory or a better outcome | ClinicalTrials.gov |
| Secondary | Systolic Blood Pressure | 12, and 24 weeks. | LMM analysis of intervention group x 12 and 24 wk test session. Baseline blood pressure entered as a covariate. | ClinicalTrials.gov |
| Secondary | Diastolic Blood Pressure | 12, and 24 weeks | LMM analysis of intervention group x 12 and 24 wk test session. Baseline blood pressure entered as a covariate. | ClinicalTrials.gov |
| Secondary | Heart Rate | 12, and 24 weeks. | LMM analysis of intervention group x 12 and 24 wk test session. Baseline heart rate entered as a covariate. | ClinicalTrials.gov |
| Secondary | Positive Affect Score | 12, and 24 weeks | As measured by the positive mood scale derived from the Positive and Negative Affect Schedule. This measure consists of 10 words relating to positive affect. The participants is asked to rate how they feel about each word from 1 (very slightly/not at all) to 5 (extremely) with a minimum score of 5 and maximum of 50. A higher score relates to higher positive affect. | ClinicalTrials.gov |
| Secondary | Negative Affect Score | 12, and 24 weeks. | As measured by the negative mood scale derived from the Positive and Negative Affect Schedule. This measure consists of 10 words relating to negative affect. The participants is asked to rate how they feel about each word from 1 (very slightly/not at all) to 5 (extremely) with a minimum score of 5 and maximum of 50. A higher score relates to higher negative affect. | ClinicalTrials.gov |
Outcomes 10
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|---|---|---|---|---|---|
| PRIMARY | Proportion of Words Correctly Recognised. | 12, and 24 weeks | proportion of words correctly recognised | MEAN | ClinicalTrials.gov | |
| PRIMARY | Total Number of Correct Sequences Recalled | 12, and 24 weeks | Correct number of sequences | MEAN | ClinicalTrials.gov | |
| PRIMARY | Combined Z Score of Delayed Words Recalled, Words Recognised, and Pictures Recognised. | 12, and 24 weeks | z-score | MEAN | ClinicalTrials.gov | |
| SECONDARY | Combined Z Score of Mean Reaction Time Scores for Incongruent Attention Network and Stroop Task Trials. | 12, and 24 weeks | z-score | MEAN | ClinicalTrials.gov | |
| SECONDARY | Combined Z Score of Proportion of Immediate Words Recalled, Number of Correct Serial 3 and Serial 7 Subtractions, Sternberg Task Coefficent of the Line | 12, and 24 weeks | z-score | MEAN | ClinicalTrials.gov | |
| SECONDARY | Systolic Blood Pressure | 12, and 24 weeks. | mmHg | MEAN | ClinicalTrials.gov | |
| SECONDARY | Diastolic Blood Pressure | 12, and 24 weeks | mmHg | MEAN | ClinicalTrials.gov | |
| SECONDARY | Heart Rate | 12, and 24 weeks. | beats/min | MEAN | ClinicalTrials.gov | |
| SECONDARY | Positive Affect Score | 12, and 24 weeks | units on a scale | MEAN | ClinicalTrials.gov | |
| SECONDARY | Negative Affect Score | 12, and 24 weeks. | units on a scale | MEAN | ClinicalTrials.gov |
Results by group 80
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|---|---|---|---|---|---|
| Proportion of Words Correctly Recognised. | Placebo | 12 Weeks | 0.86 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Wild Blueberry Powder - 450mg | 12 Weeks | 0.85 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Wild Blueberry Powder - 900 mg | 12 Weeks | 0.79 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Wild Blueberry Extract 100mg | 12 Weeks | 0.90 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Placebo | 24 Weeks | 0.90 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Wild Blueberry Powder - 450mg | 24 Weeks | 0.88 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Wild Blueberry Powder - 900 mg | 24 Weeks | 0.87 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Proportion of Words Correctly Recognised. | Wild Blueberry Extract 100mg | 24 Weeks | 0.88 | Standard Error 0.02 | proportion of words correctly recognised | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Placebo | 12 Weeks | 15.15 | Standard Error 0.41 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Wild Blueberry Powder - 450mg | 12 Weeks | 14.27 | Standard Error 0.40 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Wild Blueberry Powder - 900 mg | 12 Weeks | 15.42 | Standard Error 0.39 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Wild Blueberry Extract 100mg | 12 Weeks | 16.19 | Standard Error 0.39 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Placebo | 24 Weeks | 15.56 | Standard Error 0.48 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Wild Blueberry Powder - 450mg | 24 Weeks | 16.348 | Standard Error 0.47 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Wild Blueberry Powder - 900 mg | 24 Weeks | 15.921 | Standard Error 0.46 | Correct number of sequences | ClinicalTrials.gov |
| Total Number of Correct Sequences Recalled | Wild Blueberry Extract 100mg | 24 Weeks | 16.302 | Standard Error 0.46 | Correct number of sequences | ClinicalTrials.gov |
| Combined Z Score of Delayed Words Recalled, Words Recognised, and Pictures Recognised. | Placebo | 12 Weeks | 0.19 | Standard Error 0.11 | z-score | ClinicalTrials.gov |
| Combined Z Score of Delayed Words Recalled, Words Recognised, and Pictures Recognised. | Wild Blueberry Powder - 450mg | 12 Weeks | 0.08 | Standard Error 0.11 | z-score | ClinicalTrials.gov |
| Combined Z Score of Delayed Words Recalled, Words Recognised, and Pictures Recognised. | Wild Blueberry Powder - 900 mg | 12 Weeks | 0.02 | Standard Error 0.11 | z-score | ClinicalTrials.gov |
| Combined Z Score of Delayed Words Recalled, Words Recognised, and Pictures Recognised. | Wild Blueberry Extract 100mg | 12 Weeks | 0.28 | Standard Error 0.11 | z-score | ClinicalTrials.gov |
Participant flow 24
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|---|---|---|---|---|
| Zero to Twelve Weeks. | STARTED | Placebo | 30 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | STARTED | Wild Blueberry Powder - 450mg | 30 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | STARTED | Wild Blueberry Powder - 900 mg | 31 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | STARTED | Wild Blueberry Extract 100mg | 31 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | COMPLETED | Placebo | 27 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | COMPLETED | Wild Blueberry Powder - 450mg | 29 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | COMPLETED | Wild Blueberry Powder - 900 mg | 31 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | COMPLETED | Wild Blueberry Extract 100mg | 29 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | NOT COMPLETED | Placebo | 3 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | NOT COMPLETED | Wild Blueberry Powder - 450mg | 1 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | NOT COMPLETED | Wild Blueberry Powder - 900 mg | 0 | ClinicalTrials.gov | |
| Zero to Twelve Weeks. | NOT COMPLETED | Wild Blueberry Extract 100mg | 2 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | STARTED | Placebo | 27 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | STARTED | Wild Blueberry Powder - 450mg | 29 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | STARTED | Wild Blueberry Powder - 900 mg | 31 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | STARTED | Wild Blueberry Extract 100mg | 29 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | COMPLETED | Placebo | 27 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | COMPLETED | Wild Blueberry Powder - 450mg | 28 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | COMPLETED | Wild Blueberry Powder - 900 mg | 29 | ClinicalTrials.gov | |
| Thirteen to Twenty Four Weeks | COMPLETED | Wild Blueberry Extract 100mg | 28 | ClinicalTrials.gov |
Adverse events 4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|---|---|---|---|---|---|---|
| other | Diarrhoea / Looser Stool | Gastrointestinal disorders | Placebo | 1 | 30 | ClinicalTrials.gov | |
| other | Diarrhoea / Looser Stool | Gastrointestinal disorders | Wild Blueberry Powder - 500mg | 0 | 30 | ClinicalTrials.gov | |
| other | Diarrhoea / Looser Stool | Gastrointestinal disorders | Wild Blueberry Powder - 1000 mg | 1 | 31 | ClinicalTrials.gov | |
| other | Diarrhoea / Looser Stool | Gastrointestinal disorders | Wild Blueberry Extract 111mg | 2 | 31 | ClinicalTrials.gov |
Adverse event totals 12
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|---|---|---|---|
| Total, all-cause mortality | Placebo | 0 | 30 | ClinicalTrials.gov |
| Total, all-cause mortality | Wild Blueberry Powder - 500mg | 0 | 30 | ClinicalTrials.gov |
| Total, all-cause mortality | Wild Blueberry Powder - 1000 mg | 0 | 31 | ClinicalTrials.gov |
| Total, all-cause mortality | Wild Blueberry Extract 111mg | 0 | 31 | ClinicalTrials.gov |
| Total, other adverse events | Placebo | 1 | 30 | ClinicalTrials.gov |
| Total, other adverse events | Wild Blueberry Powder - 500mg | 0 | 30 | ClinicalTrials.gov |
| Total, other adverse events | Wild Blueberry Powder - 1000 mg | 1 | 31 | ClinicalTrials.gov |
| Total, other adverse events | Wild Blueberry Extract 111mg | 2 | 31 | ClinicalTrials.gov |
| Total, serious adverse events | Placebo | 0 | 30 | ClinicalTrials.gov |
| Total, serious adverse events | Wild Blueberry Powder - 500mg | 0 | 30 | ClinicalTrials.gov |
| Total, serious adverse events | Wild Blueberry Powder - 1000 mg | 0 | 31 | ClinicalTrials.gov |
| Total, serious adverse events | Wild Blueberry Extract 111mg | 0 | 31 | ClinicalTrials.gov |
Papers 5
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 2
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Sternberg Memory Scanning | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)