Trial · NCT02455518
Comparative Efficacy of 4 Oral Analgesics
NCT02455518, Phase 4, Completed, Montefiore Medical Center; results first posted 2018-02-13
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Comparative Efficacy of 4 Oral Analgesics. Trials, record NCT02455518. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02455518
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Comparative Efficacy of 4 Oral Analgesics
- NCT number
- NCT02455518
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 416 participants, actual
- Lead sponsor
- Montefiore Medical Center
- Conditions
- Pain
- Interventions
- Oxycodone/acetaminophen, Hydrocodone/acetaminophen, Codeine/acetaminophen, Ibuprofen/acetaminophen
- First posted
- 2015-05-28
- Last updated
- 2018-02-13
- Results first posted
- 2018-02-13
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | 2 hours | Change in numerical rating scale (NRS) pre and 2 hours post receiving study medication while in the ED. The NRS is a validated 11-point numerical scale that ranges from 0 (no pain) to 10 (worst pain possible) |
| Secondary | Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | 1 hour | Change in numerical rating scale (NRS) pre and 1-hour post receiving study medication while in the ED. The NRS is a validated 11-point numerical scale that ranges from 0 (no pain) to 10 (worst pain possible) |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | 2 hours | units on a scale | NUMBER | |
| SECONDARY | Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | 1 hour | units on a scale | NUMBER |
Source ClinicalTrials.gov
Results by group8
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Oxycodone/Acetaminophen | 4.4 | 95% Confidence Interval 3.7 to 5.0 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Hydrocodone/Acetaminophen | 3.5 | 95% Confidence Interval 2.9 to 4.2 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Codeine/Acetaminophen | 3.9 | 95% Confidence Interval 3.2 to 4.5 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Ibuprofen/Acetaminophen | 4.3 | 95% Confidence Interval 3.6 to 4.9 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Oxycodone/Acetaminophen | 3.1 | 95% Confidence Interval 2.6 to 3.7 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Hydrocodone/Acetaminophen | 2.4 | 95% Confidence Interval 1.8 to 3.0 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Codeine/Acetaminophen | 2.7 | 95% Confidence Interval 2.1 to 3.3 | units on a scale | |
| Between Group Difference in Change in Numerical Rating Scale (NRS) Pain Scores | Ibuprofen/Acetaminophen | 2.9 | 95% Confidence Interval 2.4 to 3.5 | units on a scale |
Source ClinicalTrials.gov
Participant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Oxycodone/Acetaminophen | 104 | |
| Overall Study | STARTED | Hydrocodone/Acetaminophen | 104 | |
| Overall Study | STARTED | Codeine/Acetaminophen | 104 | |
| Overall Study | STARTED | Ibuprofen/Acetaminophen | 104 | |
| Overall Study | COMPLETED | Oxycodone/Acetaminophen | 104 | |
| Overall Study | COMPLETED | Hydrocodone/Acetaminophen | 103 | |
| Overall Study | COMPLETED | Codeine/Acetaminophen | 103 | |
| Overall Study | COMPLETED | Ibuprofen/Acetaminophen | 101 | |
| Overall Study | NOT COMPLETED | Oxycodone/Acetaminophen | 0 | |
| Overall Study | NOT COMPLETED | Hydrocodone/Acetaminophen | 1 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals12
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Oxycodone/Acetaminophen | 0 | 0 |
| Total, all-cause mortality | Hydrocodone/Acetaminophen | 0 | 0 |
| Total, all-cause mortality | Codeine/Acetaminophen | 0 | 0 |
| Total, all-cause mortality | Ibuprofen/Acetaminophen | 0 | 0 |
| Total, other adverse events | Oxycodone/Acetaminophen | 0 | 0 |
| Total, other adverse events | Hydrocodone/Acetaminophen | 0 | 0 |
| Total, other adverse events | Codeine/Acetaminophen | 0 | 0 |
| Total, other adverse events | Ibuprofen/Acetaminophen | 0 | 0 |
| Total, serious adverse events | Oxycodone/Acetaminophen | 0 | 0 |
| Total, serious adverse events | Hydrocodone/Acetaminophen | 0 | 0 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 adverse event totalsPapers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 29114833 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02455518
GET https://conductscience.org/api/trials/v1/NCT02455518/registered