Brain Connectivity and Response to Tai Chi in Geriatric Depression

NCT02460666, Not applicable, Completed, University of California, Los Angeles; results first posted 2021-07-09

Trial 12

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Field	Value	Source
Title	Brain Connectivity and Response to Tai Chi in Geriatric Depression	ClinicalTrials.gov
NCT number	NCT02460666	ClinicalTrials.gov
Status	Completed	ClinicalTrials.gov
Phases	Not applicable	ClinicalTrials.gov
Enrollment	220 participants, actual	ClinicalTrials.gov
Lead sponsor	University of California, Los Angeles	ClinicalTrials.gov
Conditions	Major Depressive Disorder	ClinicalTrials.gov
Interventions	Tai-Chi-Chih (TCC), Health Education and Wellness Classes (HEW)	ClinicalTrials.gov
First posted	2015-06-02	ClinicalTrials.gov
Last updated	2021-07-16	ClinicalTrials.gov
Results first posted	2021-07-09	ClinicalTrials.gov
Limitations and caveats	After March 18th, 2020, all assessments were completed remotely due to COVID-19 until restrictions were lifted for eligible participants to come in-person.	ClinicalTrials.gov

Registered outcomes 5

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description	Source
Primary	Change in Hamilton Depression Rating Scale (HDRS) Scores	Measured at baseline and 3 months	Clinician administered scale measures severity of depressive symptoms. This measure includes 24 items. Response options vary item to item and include the following ranges: \[0-2\], \[0-3\], and \[0-4\]. A score of 0 suggests absence of symptoms and/or difficulties and higher scores represent more severe difficulties. Possible overall score range \[0-74\], higher scores representing more severe difficulties.	ClinicalTrials.gov
Secondary	Change in Delayed Recall Cognitive Domain Scores	Measured at baseline and 3 months	Neuropsychological battery of tests which included the following domains: Delayed Recall (CVLT-II \[Long-Delay Free Recall\], Rey-Osterrieth Complex Figure Test \[30-minute Delayed Recall\]) Raw scores were transformed to z-scores (with a mean of 0 and standard deviation of 1) for each test score of interest across all participants. Thus the sample mean (across both arms) is zero for each test score. These z-scores were then averaged within each neuropsychological domain to produce composite scores. Higher scores are indicative of better performance.	ClinicalTrials.gov
Secondary	Change in Attention/Executive Function Cognitive Domain Scores	Measured at baseline and 3 months	Neuropsychological battery of tests which included the following domains: Attention/Executive Function (Trail Making Test A and B, Stroop Interference \[Golden version\]) Raw scores were transformed to z-scores (with a mean of 0 and standard deviation of 1) for each test score of interest across all participants. Thus the sample mean (across both arms) is zero for each test score. These z-scores were then averaged within each neuropsychological domain to produce composite scores. Higher scores are indicative of better performance.	ClinicalTrials.gov
Secondary	Change in Language Cognitive Domain Scores	Measured at baseline and 3 months	Neuropsychological battery of tests which included the following domains: Language (Controlled Oral Word Association test \[FAS\], Animal Fluency, and Boston Naming Test) Raw scores were transformed to z-scores (with a mean of 0 and standard deviation of 1) for each test score of interest across all participants. Thus the sample mean (across both arms) is zero for each test score. These z-scores were then averaged within each neuropsychological domain to produce composite scores. Higher scores are indicative of better performance.	ClinicalTrials.gov
Other	Number of Participants With Adverse Events	Measured at 3 months	The UKU (Udvalg for Kliniske Undersogelser) Side Effect Rating Scale organizes symptoms into 4 categories (i.e., Psychic, Neurologic, Autonomic, Other) containing 8-19 symptoms each. Each symptom receives a score for degree and causal relationship. Degree is scored between 0-3 with higher scores being more severe. Causal relationship is scored as improbable, possible, or probable.	ClinicalTrials.gov

Outcomes 5

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as	Source
PRIMARY	Change in Hamilton Depression Rating Scale (HDRS) Scores	Measured at baseline and 3 months	units on a scale	MEAN	ClinicalTrials.gov
SECONDARY	Change in Delayed Recall Cognitive Domain Scores	Measured at baseline and 3 months	z-score	MEAN	ClinicalTrials.gov
SECONDARY	Change in Attention/Executive Function Cognitive Domain Scores	Measured at baseline and 3 months	z-score	MEAN	ClinicalTrials.gov
SECONDARY	Change in Language Cognitive Domain Scores	Measured at baseline and 3 months	z-score	MEAN	ClinicalTrials.gov
OTHER_PRE_SPECIFIED	Number of Participants With Adverse Events	Measured at 3 months	Participants	COUNT_OF_PARTICIPANTS	ClinicalTrials.gov

Results by group 10

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units	Source
Change in Hamilton Depression Rating Scale (HDRS) Scores	Tai-Chi Chih Classes	-9.27	Standard Deviation 5.29	units on a scale	ClinicalTrials.gov
Change in Hamilton Depression Rating Scale (HDRS) Scores	Health Education and Wellness Classes	-9.40	Standard Deviation 5.35	units on a scale	ClinicalTrials.gov
Change in Delayed Recall Cognitive Domain Scores	Tai-Chi Chih Classes	-0.15	Standard Deviation 0.57	z-score	ClinicalTrials.gov
Change in Delayed Recall Cognitive Domain Scores	Health Education and Wellness Classes	-0.002	Standard Deviation 0.61	z-score	ClinicalTrials.gov
Change in Attention/Executive Function Cognitive Domain Scores	Tai-Chi Chih Classes	-0.04	Standard Deviation 0.61	z-score	ClinicalTrials.gov
Change in Attention/Executive Function Cognitive Domain Scores	Health Education and Wellness Classes	0.03	Standard Deviation 0.53	z-score	ClinicalTrials.gov
Change in Language Cognitive Domain Scores	Tai-Chi Chih Classes	0.03	Standard Deviation 0.40	z-score	ClinicalTrials.gov
Change in Language Cognitive Domain Scores	Health Education and Wellness Classes	-0.12	Standard Deviation 0.46	z-score	ClinicalTrials.gov
Number of Participants With Adverse Events	Tai-Chi Chih Classes	4		Participants	ClinicalTrials.gov
Number of Participants With Adverse Events	Health Education and Wellness Classes	3		Participants	ClinicalTrials.gov

Participant flow 6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants	Source
Overall Study	STARTED	Tai-Chi Chih Classes	89	ClinicalTrials.gov
Overall Study	STARTED	Health Education and Wellness Classes	89	ClinicalTrials.gov
Overall Study	COMPLETED	Tai-Chi Chih Classes	62	ClinicalTrials.gov
Overall Study	COMPLETED	Health Education and Wellness Classes	63	ClinicalTrials.gov
Overall Study	NOT COMPLETED	Tai-Chi Chih Classes	27	ClinicalTrials.gov
Overall Study	NOT COMPLETED	Health Education and Wellness Classes	26	ClinicalTrials.gov

Adverse events 6

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events	Source
other	Asthenia/Lassitude/Increased Fatigability	Musculoskeletal and connective tissue disorders	Tai-Chi Chih Classes	4	89	4	ClinicalTrials.gov
other	Asthenia/Lassitude/Increased Fatigability	Musculoskeletal and connective tissue disorders	Health Education and Wellness Classes	0	89	0	ClinicalTrials.gov
other	Failing memory	Psychiatric disorders	Tai-Chi Chih Classes	0	89	0	ClinicalTrials.gov
other	Failing memory	Psychiatric disorders	Health Education and Wellness Classes	1	89	1	ClinicalTrials.gov
other	Tension/Inner Unrest	Psychiatric disorders	Tai-Chi Chih Classes	0	89	0	ClinicalTrials.gov
other	Tension/Inner Unrest	Psychiatric disorders	Health Education and Wellness Classes	2	89	2	ClinicalTrials.gov

Adverse event totals 6

The totals the trial posted for each group.

Total	Group	Affected	At risk	Source
Total, all-cause mortality	Tai-Chi Chih Classes	0	89	ClinicalTrials.gov
Total, all-cause mortality	Health Education and Wellness Classes	0	89	ClinicalTrials.gov
Total, other adverse events	Tai-Chi Chih Classes	4	89	ClinicalTrials.gov
Total, other adverse events	Health Education and Wellness Classes	3	89	ClinicalTrials.gov
Total, serious adverse events	Tai-Chi Chih Classes	0	89	ClinicalTrials.gov
Total, serious adverse events	Health Education and Wellness Classes	0	89	ClinicalTrials.gov

Papers 6

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
21358389	BACKGROUND	PubMed
21857219	BACKGROUND	PubMed
23538081	BACKGROUND	PubMed
23642461	BACKGROUND	PubMed
25142571	BACKGROUND	PubMed
34404606	DERIVED	PubMed

Grants 1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years	Source
R01AT008383	Brain connectivity and response to Tai Chi in geriatric depression	LAVRETSKY, HELEN	UNIVERSITY OF CALIFORNIA LOS ANGELES	NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH	2015 to 2019	NIH RePORTER

Trial comparisons 3

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Tai-Chi Chih Classes vs Health Education and Wellness Classes: Number of Participants With Adverse Events	Trial comparisons
Tai-Chi Chih Classes vs Health Education and Wellness Classes: deaths from any cause	Trial comparisons
Tai-Chi Chih Classes vs Health Education and Wellness Classes: serious adverse events	Trial comparisons

Tests 7

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

Test	Named as	Source
Category Fluency	Secondary outcome	ConductCognition
Complex Figure Copy and Recall	Secondary outcome	ConductCognition
Picture Naming Test	Secondary outcome	ConductCognition
Stroop Color-Word Test	Secondary outcome	ConductCognition
Trail Making Test A	Secondary outcome	ConductCognition
Trail Making Test B	Secondary outcome	ConductCognition
Verbal Fluency	Secondary outcome	ConductCognition

Source 5

Field	Value	Source
Release	trials-2026-11-12-0.4.0	ClinicalTrials.gov
Release manifest SHA-256	0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4	ClinicalTrials.gov
Registry capture	2026-11-12	ClinicalTrials.gov
Results copy, AACT	2026-03-23	ClinicalTrials.gov
NIH clinical studies file	2026-11-13	ClinicalTrials.gov

The same record as JSON

Release trials-2026-11-12-0.4.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)