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A Study of AG-348 in Adult Participants With Pyruvate Kinase (PK) Deficiency
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Trial · NCT02476916

Results by group86

Each measurement the trial posted, group by group, in the words and numbers it posted.

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OutcomeGroupCategoryValueSpreadUnits
Percentage of Participants Experiencing at Least One Adverse Event (AEs) in the Core PeriodAG-348 50 mg BID96.3percentage of participants
Percentage of Participants Experiencing at Least One Adverse Event (AEs) in the Core PeriodAG-348 300 mg BID100.0percentage of participants
Change From Baseline in Hemoglobin (Hb) Value at Week 24AG-348 50 mg BIDBaseline9.243Standard Deviation 1.4757grams per deciliter (g/dL)
Change From Baseline in Hemoglobin (Hb) Value at Week 24AG-348 300 mg BIDBaseline8.636Standard Deviation 1.1664grams per deciliter (g/dL)
Change From Baseline in Hemoglobin (Hb) Value at Week 24AG-348 50 mg BIDChange at Week 241.205Standard Deviation 1.4181grams per deciliter (g/dL)
Change From Baseline in Hemoglobin (Hb) Value at Week 24AG-348 300 mg BIDChange at Week 241.611Standard Deviation 1.7058grams per deciliter (g/dL)
Change From Baseline in Hematocrit at Week 24AG-348 50 mg BIDBaseline0.289Standard Deviation 0.0470volume per volume (V/V)
Change From Baseline in Hematocrit at Week 24AG-348 300 mg BIDBaseline0.268Standard Deviation 0.0367volume per volume (V/V)
Change From Baseline in Hematocrit at Week 24AG-348 50 mg BIDChange at Week 240.033Standard Deviation 0.0414volume per volume (V/V)
Change From Baseline in Hematocrit at Week 24AG-348 300 mg BIDChange at Week 240.045Standard Deviation 0.0499volume per volume (V/V)
Change From Baseline in Reticulocyte Count at Week 24AG-348 50 mg BIDBaseline493.248Standard Deviation 234.2242cells * 10^9/liter
Change From Baseline in Reticulocyte Count at Week 24AG-348 300 mg BIDBaseline549.436Standard Deviation 291.5301cells * 10^9/liter
Change From Baseline in Reticulocyte Count at Week 24AG-348 50 mg BIDChange at Week 24-99.248Standard Deviation 309.9473cells * 10^9/liter
Change From Baseline in Reticulocyte Count at Week 24AG-348 300 mg BIDChange at Week 24-46.222Standard Deviation 351.9823cells * 10^9/liter
Change From Baseline in Haptoglobin at Week 24AG-348 50 mg BIDBaseline0.246Standard Deviation 0.1474gram per liter (g/L)
Change From Baseline in Haptoglobin at Week 24AG-348 300 mg BIDBaseline0.240Standard Deviation 0.2082gram per liter (g/L)
Change From Baseline in Haptoglobin at Week 24AG-348 50 mg BIDChange at Week 240.128Standard Deviation 0.2845gram per liter (g/L)
Change From Baseline in Haptoglobin at Week 24AG-348 300 mg BIDChange at Week 240.139Standard Deviation 0.2726gram per liter (g/L)
Change From Baseline in Carbon Monoxide at Week 24AG-348 50 mg BIDBaseline5.263Standard Deviation 1.7270percentage Hb bound to carbon monoxide
Change From Baseline in Carbon Monoxide at Week 24AG-348 300 mg BIDBaseline6.200Standard Deviation 2.3079percentage Hb bound to carbon monoxide

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

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Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

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