Trial · NCT02479451
Helping Olfaction and Nutrition On Renal Replacement
NCT02479451, Phase 2, Completed, Massachusetts General Hospital; results first posted 2024-01-09
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Helping Olfaction and Nutrition On Renal Replacement. Trials, record NCT02479451. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02479451
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Helping Olfaction and Nutrition On Renal Replacement
- NCT number
- NCT02479451
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 7 participants, actual
- Lead sponsor
- Massachusetts General Hospital
- Conditions
- End Stage Renal Disease, Olfactory Disorders
- Interventions
- Theophylline
- First posted
- 2015-06-24
- Last updated
- 2024-01-09
- Results first posted
- 2024-01-09
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Smell Identification Test Score at 6 Weeks | Baseline and every 2 weeks for 6 weeks | Smell identification test is a validated 40-item scratch and sniff smell identification test that was administered by study investigators. Scores on this test scale range between 0 (minimum) to 40 (maximum). Higher score indicates better ability for smell identification. Total scores are reported on this scale (no sub-scales). The unit is score on this scale. |
| Primary | Change From Baseline in Smell Threshold Test Score at 6 Weeks | Baseline and every 2 weeks for 6 weeks | This test determined the lowest concentration of an odor compound that is perceivable by study participants. Scores on this test scale range between -2 and -10. Higher score indicates higher smell detection threshold (i.e. worse ability to smell). Total scores are reported on this scale (no sub-scales). The unit is score on this scale. |
| Secondary | Change From Baseline in Plasma Theophylline Level at 6 Weeks | Baseline and every 2 weeks for 6 weeks | Plasma levels of theophylline were measured using fluorescence polarization technique. Minimum level will be 0 microgram/mL and maximum assay limit is 40 microgram/mL. Higher levels indicate increased systemic exposure to theophylline. Units on scale are microgram/mL. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change From Baseline in Smell Identification Test Score at 6 Weeks | Baseline and every 2 weeks for 6 weeks | units on a scale | MEAN | |
| PRIMARY | Change From Baseline in Smell Threshold Test Score at 6 Weeks | Baseline and every 2 weeks for 6 weeks | change in score on the scale | MEAN | |
| SECONDARY | Change From Baseline in Plasma Theophylline Level at 6 Weeks | Baseline and every 2 weeks for 6 weeks | Serum theophylline levels assessed at every follow-up were undetectable throughout the study period in all participants. | microgram/mL | MEAN |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change From Baseline in Smell Identification Test Score at 6 Weeks | Nasal Theophylline | 4 | Standard Error 2 | units on a scale | |
| Change From Baseline in Smell Threshold Test Score at 6 Weeks | Nasal Theophylline | -1 | Standard Error 2 | change in score on the scale | |
| Change From Baseline in Plasma Theophylline Level at 6 Weeks | Nasal Theophylline | 0 | Standard Deviation 0 | microgram/mL |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Nasal Theophylline | 7 | |
| Overall Study | COMPLETED | Nasal Theophylline | 7 | |
| Overall Study | NOT COMPLETED | Nasal Theophylline | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Nasal Theophylline | 0 | 7 |
| Total, other adverse events | Nasal Theophylline | 0 | 7 |
| Total, serious adverse events | Nasal Theophylline | 0 | 7 |
Source ClinicalTrials.gov
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02479451
GET https://conductscience.org/api/trials/v1/NCT02479451/registered