Trial · NCT02494180
A Non-inferiority Trial on Pain Relief During Oocyte Retrieval
NCT02494180, Phase 4, Completed, Kwong Wah Hospital; results first posted 2019-03-05
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Non-inferiority Trial on Pain Relief During Oocyte Retrieval. Trials, record NCT02494180. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02494180
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Non-inferiority Trial on Pain Relief During Oocyte Retrieval
- NCT number
- NCT02494180
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 170 participants, actual
- Lead sponsor
- Kwong Wah Hospital
- Conditions
- Infertility
- Interventions
- fentanyl, pethidine, Diazepam, Midazolam
- First posted
- 2015-07-10
- Last updated
- 2019-03-05
- Results first posted
- 2019-03-05
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Pain Level During Oocyte Retrieval | will be assessed within 4 hours of oocyte retrieval | The pain level will be scored using visual analogue scale 0-10, 0 = no pain, 10 =most painful |
| Primary | Pain Level After Oocyte Retrieval | will be assessed within 4 hours of oocyte retrieval | The pain level will be scored using visual analogue scale 0-10, 0 = no pain, 10 =most painful |
| Secondary | Percentage of Participants With Side Effects by Type | will be assessed within 4 hours of oocyte retrieval | side effects will be scored by yes or no |
| Secondary | Patient's Satisfaction on Oocyte Retrieval | will be assessed within 4 hours of oocyte retrieval | satisfaction will be scored from 0-3 (0=excellent, 1=satisfactory, 2=fair, 3=unsatisfactory) |
| Secondary | Clinical Pregnancy Rate | will be assessed within ten weeks of oocyte retrieval | presence of intrauterine sac in ultrasound after a positive pregnancy test |
| Secondary | Ongoing Pregnancy Rate | will be assessed within ten weeks of oocyte retrieval | positive fetal heart pulsation seen in ultrasound at eight weeks of gestation |
| Secondary | Patient's Satisfaction on Pain Relief | within 4 hours after retrieval | satisfaction on pain relief will be scored at 0-10 (10 being most satisfied) |
| Secondary | Sedation Level | immediately after retrieval | S = sleeping, easily aroused; 1 = awake and alert; 2 = occasionally drowsy, easy to arouse; 3 = frequently drowsy, arousable, drifts off to sleep during conversation; 4 = somnolent, minimal or no response to stimuli |
Source ClinicalTrials.gov
Outcomes8
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Pain Level During Oocyte Retrieval | will be assessed within 4 hours of oocyte retrieval | score on a scale | MEDIAN | |
| PRIMARY | Pain Level After Oocyte Retrieval | will be assessed within 4 hours of oocyte retrieval | score on a scale | MEDIAN | |
| SECONDARY | Percentage of Participants With Side Effects by Type | will be assessed within 4 hours of oocyte retrieval | percentage of participants | NUMBER | |
| SECONDARY | Patient's Satisfaction on Oocyte Retrieval | will be assessed within 4 hours of oocyte retrieval | percentage of participants | NUMBER | |
| SECONDARY | Clinical Pregnancy Rate | will be assessed within ten weeks of oocyte retrieval | percentage of participants | NUMBER | |
| SECONDARY | Ongoing Pregnancy Rate | will be assessed within ten weeks of oocyte retrieval | percentage of participants | NUMBER | |
| SECONDARY | Patient's Satisfaction on Pain Relief | within 4 hours after retrieval | score on a scale | MEDIAN | |
| SECONDARY | Sedation Level | immediately after retrieval | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group44
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Pain Level During Oocyte Retrieval | A: Intravenous Fentanyl, Midazolam | vaginal pain | 0 | Inter-Quartile Range 0 to 2.5 | score on a scale |
| Pain Level During Oocyte Retrieval | B: Intravenous Pethidine, Diazepam | vaginal pain | 4 | Inter-Quartile Range 1 to 7 | score on a scale |
| Pain Level During Oocyte Retrieval | A: Intravenous Fentanyl, Midazolam | abdominal pain | 2.5 | Inter-Quartile Range 0 to 5 | score on a scale |
| Pain Level During Oocyte Retrieval | B: Intravenous Pethidine, Diazepam | abdominal pain | 5 | Inter-Quartile Range 2.5 to 7.5 | score on a scale |
| Pain Level After Oocyte Retrieval | A: Intravenous Fentanyl, Midazolam | vaginal pain | 0 | Inter-Quartile Range 0 to 2 | score on a scale |
| Pain Level After Oocyte Retrieval | B: Intravenous Pethidine, Diazepam | vaginal pain | 0 | Inter-Quartile Range 0 to 2.5 | score on a scale |
| Pain Level After Oocyte Retrieval | A: Intravenous Fentanyl, Midazolam | abdominal pain | 2.3 | Inter-Quartile Range 0 to 2.8 | score on a scale |
| Pain Level After Oocyte Retrieval | B: Intravenous Pethidine, Diazepam | abdominal pain | 2 | Inter-Quartile Range 0 to 3 | score on a scale |
| Percentage of Participants With Side Effects by Type | A: Intravenous Fentanyl, Midazolam | nausea | 2.4 | percentage of participants | |
| Percentage of Participants With Side Effects by Type | B: Intravenous Pethidine, Diazepam | nausea | 7.1 | percentage of participants |
1 to 10 of 44Source ClinicalTrials.gov
See all 44 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | A: Intravenous Fentanyl, Midazolam | 85 | |
| Overall Study | STARTED | B: Intravenous Pethidine, Diazepam | 85 | |
| Overall Study | COMPLETED | A: Intravenous Fentanyl, Midazolam | 85 | |
| Overall Study | COMPLETED | B: Intravenous Pethidine, Diazepam | 85 | |
| Overall Study | NOT COMPLETED | A: Intravenous Fentanyl, Midazolam | 0 | |
| Overall Study | NOT COMPLETED | B: Intravenous Pethidine, Diazepam | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | A: Intravenous Fentanyl, Midazolam | 0 | 85 |
| Total, all-cause mortality | B: Intravenous Pethidine, Diazepam | 0 | 85 |
| Total, other adverse events | A: Intravenous Fentanyl, Midazolam | 0 | 85 |
| Total, other adverse events | B: Intravenous Pethidine, Diazepam | 0 | 85 |
| Total, serious adverse events | A: Intravenous Fentanyl, Midazolam | 0 | 85 |
| Total, serious adverse events | B: Intravenous Pethidine, Diazepam | 0 | 85 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| A: Intravenous Fentanyl, Midazolam vs B: Intravenous Pethidine, Diazepam: deaths from any cause | Trial comparisons |
| A: Intravenous Fentanyl, Midazolam vs B: Intravenous Pethidine, Diazepam: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02494180
GET https://conductscience.org/api/trials/v1/NCT02494180/results?page=2