Trial · NCT02512809
Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
NCT02512809, Phase 3, Terminated, Nationwide Children's Hospital; results first posted 2018-12-13
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Isoflurane-induced Neuroinflammation in Children With Hydrocephalus. Trials, record NCT02512809. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02512809
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Isoflurane-induced Neuroinflammation in Children With Hydrocephalus
- NCT number
- NCT02512809
- Status
- Terminated
- Phases
- Phase 3
- Enrollment
- 25 participants, actual
- Lead sponsor
- Nationwide Children's Hospital
- Conditions
- Toxicity, Hydrocephalus
- Interventions
- Isoflurane, Dexmedetomidine
- First posted
- 2015-07-31
- Last updated
- 2018-12-13
- Results first posted
- 2018-12-13
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Serum Cytokine Levels | On the day of surgery or MRI from start of procedure to discharge from PACU (approx. 1-7 hrs.) | Surgery subjects will have blood collected once at the start of surgery, once at the end of surgery, and once in the PACU. MRI patients will have blood collected once prior to the start of the MRI and once at the completion of the MRI. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Serum Cytokine Levels | On the day of surgery or MRI from start of procedure to discharge from PACU (approx. 1-7 hrs.) | pg/ml | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Serum Cytokine Levels | MRI Control Arm | IL-1β pre-isoflurane | 25.97 | Standard Deviation 9.01 | pg/ml |
| Change in Serum Cytokine Levels | MRI Control Arm | IL-1β post-isoflurane | 38.53 | Standard Deviation 16.56 | pg/ml |
| Change in Serum Cytokine Levels | MRI Control Arm | TNF-α pre-isoflurane | 94.26 | Standard Deviation 18.07 | pg/ml |
| Change in Serum Cytokine Levels | MRI Control Arm | TNF-α post-isoflurane | 85.84 | Standard Deviation 12.12 | pg/ml |
| Change in Serum Cytokine Levels | MRI Control Arm | IL-6 pre-isoflurane | 2.28 | Standard Deviation 2.27 | pg/ml |
| Change in Serum Cytokine Levels | MRI Control Arm | IL-6 post-isoflurane | 2.04 | Standard Deviation 2.15 | pg/ml |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | MRI Control Arm | 25 | |
| Overall Study | COMPLETED | MRI Control Arm | 25 | |
| Overall Study | NOT COMPLETED | MRI Control Arm | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | MRI Control Arm | 0 | 25 |
| Total, other adverse events | MRI Control Arm | 0 | 25 |
| Total, serious adverse events | MRI Control Arm | 0 | 25 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02512809
GET https://conductscience.org/api/trials/v1/NCT02512809/registered