Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD)
NCT02535884, Not applicable, Completed, Heinrich-Heine University, Duesseldorf
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Deep Brain Stimulation (DBS) of the Globus Pallidus (GP) in Huntington's Disease (HD) | ClinicalTrials.gov |
| NCT number | NCT02535884 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 48 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Heinrich-Heine University, Duesseldorf | ClinicalTrials.gov |
| Conditions | Huntington Disease | ClinicalTrials.gov |
| Interventions | ACTIVA® PC neurostimulator (Model 37601) | ClinicalTrials.gov |
| First posted | 2015-08-31 | ClinicalTrials.gov |
| Last updated | 2022-01-21 | ClinicalTrials.gov |
Registered outcomes 13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | UHDRS-TMS difference | 12 weeks postoperatively compared to baseline | Difference between the groups in the UHDRS total motor score (UHDRS-TMS) at 12 weeks postoperatively compared to baseline. | ClinicalTrials.gov |
| Secondary | UHDRS-Chorea difference | 6 months postoperatively compared to baseline | Difference in the Unified Huntington's Disease Rating Scale (UHDRS) chorea subscore (items 14-20) | ClinicalTrials.gov |
| Secondary | UHDRS-bradykinesia difference | 6 months postoperatively compared to baseline | Difference in the UHDRS bradykinesia subscore (items 22-25 and 27-29) | ClinicalTrials.gov |
| Secondary | BFMDRS difference | 6 months postoperatively compared to baseline | Difference in the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score | ClinicalTrials.gov |
| Secondary | Reilmann Battery differences | 6 months postoperatively compared to baseline | Difference in the Q-Motor "choreomotography" test (Reilmann Battery) | ClinicalTrials.gov |
| Secondary | MDRS difference | 6 months postoperatively compared to baseline | Difference in the Mattis Dementia Rating Scale (MDRS) | ClinicalTrials.gov |
| Secondary | Verbal Fluency Test difference | 6 months postoperatively compared to baseline | Difference in the Verbal Fluency Test (formal lexical, categorical, category change) | ClinicalTrials.gov |
| Secondary | SDMT difference | 6 months postoperatively compared to baseline | Difference in the Symbol Digit Modalities Test (SDMT) | ClinicalTrials.gov |
| Secondary | STROOP Test differences | 6 months postoperatively compared to baseline | Difference in STROOP word reading, colour naming and colour of the word naming | ClinicalTrials.gov |
| Secondary | HADS-SIS difference | 6 months postoperatively compared to baseline | Difference in the Hospital Anxiety and Depression Scale combined with Snaith Irritability Scale (HADS-SIS) | ClinicalTrials.gov |
| Secondary | PBA-s difference | 6 months postoperatively compared to baseline | Difference in the Problem Behaviours Assessment Short Form (PBA-s) | ClinicalTrials.gov |
| Secondary | SF 36 difference | 6 months postoperatively compared to baseline | Difference in the Short Form (36) Health Survey (SF-36) | ClinicalTrials.gov |
| Secondary | CGI difference | 6 months postoperatively compared to baseline | Difference in the Clinical Global Impression Scale (CGI) | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 7
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)