Dissociating Components of Anhedonia: A Pilot fMRI Study
NCT02569034, Not applicable, Completed, University of Florida
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Dissociating Components of Anhedonia: A Pilot fMRI Study | ClinicalTrials.gov |
| NCT number | NCT02569034 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 46 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Florida | ClinicalTrials.gov |
| Conditions | Anhedonia | ClinicalTrials.gov |
| Interventions | Functional Magnetic Resonance Imaging, Effort-Expenditure for Rewards Task | ClinicalTrials.gov |
| First posted | 2015-10-06 | ClinicalTrials.gov |
| Last updated | 2018-11-13 | ClinicalTrials.gov |
Registered outcomes 21
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | fMRI Activity | Approximately Day 14 (Visit 2) | To quantify brain activity associated with reward "wanting," the investigators will contrast fMRI activation while participants view information about reward probability and choose to perform the easy or hard task with activity during fixation. The investigators will contrast activation during performance feedback and presentation of reward magnitude with activation during fixation to capture brain activity associated with reward "liking." Parameter estimates (ß) will be generated, which indicated relative strength of covariance between the data and the hemodynamic response function (HRF). The investigators will use a three-dimensional spatial contiguity threshold of 20 voxels and a statistical significance threshold of p ≤ .005 to decrease the likelihood of spurious findings. | ClinicalTrials.gov |
| Primary | EEfRT Task Test | Approximately Day 14 (Visit 2) | The EEfRT is a computerized task in which participants are presented with a series of repeated trials during which they choose between performing a ''hard-task'' or an ''easy-task'' in order to earn varying amounts of monetary rewards. | ClinicalTrials.gov |
| Secondary | Montreal Cognitive Assessment (MoCA) | Baseline (Visit 1) | Cognitive screening instrument. The highest possible score is 30. 18 - 26 = mild cognitive impairment, 10 - 17 = moderate cognitive impairment and less than 10 = severe cognitive impairment. | ClinicalTrials.gov |
| Secondary | Dementia Rating Scale-2 (DRS-2) | Baseline (Visit 1) | The scale includes 36 tasks which are grouped into five subscales assessing different cognitive domains, namely: Attention, Initiation/Perseveration (I/P), Construction, Conceptualization and Memory. | ClinicalTrials.gov |
| Secondary | Card Stroop Task | Baseline (Visit 1) | Participants must 1) read color words (red, green and blue) aloud, 2) name the ink color of a string of X's presented in rows on a page, and 3) name the ink color of color words (red, green, blue) written in either the same or a different color as the word meaning. | ClinicalTrials.gov |
| Secondary | Letter-Number Sequencing (Wechsler Adult Intelligence Scale, 4th Edition) | Baseline (Visit 1) | Subjects hear a string a numbers and letters and must repeat them with the numbers first, in order, followed by the letters in alphabetical order. | ClinicalTrials.gov |
| Secondary | Trail Making Test Parts A and B | Baseline (Visit 1) | The task requires a subject to 'connect-the-dots' of 25 consecutive targets on a sheet of paper or computer screen. There are two parts to the test: A, in which the targets are all numbers (1,2,3..) and the test taker needs to connect them in sequential order, and B, in which the subject alternates between numbers and letters (1, A, 2, B, etc.). The test should be finished as quickly as possible within 5 minutes. The poorer the performance the higher the impairment. | ClinicalTrials.gov |
| Secondary | Wisconsin Card Sorting Test | Baseline (Visit 1) | A number of stimulus cards are to be match within 20 minutes. Participants must figure out the sorting rule based on feedback from the examiner. | ClinicalTrials.gov |
| Secondary | Controlled Oral Word Association/Category Fluency | Baseline (Visit 1) | Subjects are asked to name as many words as they can in 60 seconds based on either a letter (F, A, and S) or a category (animals) rule. | ClinicalTrials.gov |
| Secondary | Digit Span (Wechsler Adult Intelligence Scale, 4th Edition) | Baseline (Visit 1) | Subjects repeat a string of numbers in either the same order (digits forward) or in reverse order (digits backward). | ClinicalTrials.gov |
| Secondary | California Verbal Learning Test II (CVLT-II) | Baseline (Visit 1) | Subjects are asked to learn and remember a 16-item word list. | ClinicalTrials.gov |
| Secondary | Brief Visuospatial Memory Test-Revised (BVMT-R) | Baseline (Visit 1) | Subjects are asked to learn and remember the identity and location of 6 simple figures displayed on a page. | ClinicalTrials.gov |
| Secondary | Temporal Experience of Pleasure scale (TEPS) | Baseline (Visit 1) | 18-item self-report questionnaire assessing anticipatory pleasure and consummatory pleasure | ClinicalTrials.gov |
| Secondary | Snaith-Hamilton Pleasure Scale (SHAPS) | Baseline (Visit 1) | The SHAPS measures hedonic capacity. A higher total SHAPS score will indicate a higher level of anhedonia or the inability to experience pleasure. | ClinicalTrials.gov |
| Secondary | Positive Affect Negative Affect Scale (PANAS) | Baseline (Visit 1) | Subjects are required to respond to a 20-item test using 5-point scale that ranges from very slightly or not at all (1) to extremely (5). | ClinicalTrials.gov |
| Secondary | Beck Depression Inventory, 2nd Edition (BDI-II) | Baseline (Visit 1) | 21-item self-report questionnaire assessing symptoms of depression. | ClinicalTrials.gov |
| Secondary | Geriatric Depression Scale (GDS) | Baseline (Visit 1) | Subjects answer 30 yes/no questions assessing symptoms of depression. | ClinicalTrials.gov |
| Secondary | Center for Epidemiologic Studies Depression Scale (CES-D) | Baseline (Visit 1) | This is a 20-item measure of depression severity. | ClinicalTrials.gov |
| Secondary | State-Trait Anxiety Inventory (STAI) | Baseline (Visit 1) | The STAI measures two extremes of anxiety affect, labeled state anxiety (A-State), and trait anxiety (A-Trait). Higher scores suggest higher levels of anxiety. | ClinicalTrials.gov |
| Secondary | Apathy Scale (AS) | Baseline (Visit 1) | 14-item self-report questionnaire assessing symptoms of apathy over the previous 2-4 weeks | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| R03MH109336 | Dissociating Components of Anhedonia: Pilot Behavioral and fMRI Data for the Effort Expenditure for Rewards Task | BOWERS, DAWN | UNIVERSITY OF FLORIDA | NATIONAL INSTITUTE OF MENTAL HEALTH | 2015 to 2016 | NIH RePORTER |
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 10
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Effort for Rewards Task | Primary outcome | ConductCognition |
| Card Sorting Test (Berg) | Secondary outcome | ConductCognition |
| Category Fluency | Secondary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Letter-Number Sequencing Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)