Trial · NCT02579044
Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria
NCT02579044, Phase 1, Phase 2, Enrolling by invitation, Boston Children's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria. Trials, record NCT02579044. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02579044
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Phase I/II Trial of Everolimus in Combination With Lonafarnib in Progeria
- NCT number
- NCT02579044
- Status
- Enrolling by invitation
- Phases
- Phase 1, Phase 2
- Enrollment
- 80 participants, estimated
- Lead sponsor
- Boston Children's Hospital
- Conditions
- Progeria
- Interventions
- Everolimus and lonafarnib
- First posted
- 2015-10-19
- Last updated
- 2026-04-02
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Maximum-tolerated dose (MTD) of everolimus when administered orally in combination with lonafarnib in subjects with progeria | 12 Months | For Phase I portion of protocol |
| Primary | Number and type of dose-limiting toxicities when everolimus and lonafarnib are administered in combination to children with progeria | 12 Months | For Phase I portion of protocol |
| Primary | Annual increase in weight gain | 24 Months | For Phase II portion of protocol |
| Primary | Change in pulse wave velocity (PWV) | 24 months | For Phase II portion of protocol |
| Secondary | Markers of progeria-specific activity | 24 Months | For Phase II portion of protocol |
| Secondary | Trough levels of everolimus in combination with lonafarnib in progeria | 12 months | For Phase I portion of protocol |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02579044
GET https://conductscience.org/api/trials/v1/NCT02579044/registered