Trial · NCT02594644
The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy
NCT02594644, Not applicable, Completed, University of California, Davis; results first posted 2018-11-29
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy. Trials, record NCT02594644. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02594644
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Use of Microneedles to Expedite Treatment Time in Photodynamic Therapy
- NCT number
- NCT02594644
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 32 participants, actual
- Lead sponsor
- University of California, Davis
- Conditions
- Keratosis, Actinic
- Interventions
- Microneedle Roller, Aminolevulinic Acid, Blue Light
- First posted
- 2015-11-03
- Last updated
- 2018-11-29
- Results first posted
- 2018-11-29
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Difference in the Percentage of Complete Clearance of the Actinic Keratoses | Baseline, 2 Months | The primary endpoint will be the difference in the percentage of complete clearance of the actinic keratoses as an intraindividual comparison between the treatment groups. |
| Secondary | Visual Analog Pain Scale | Immediately Post-Treatment | The secondary will be any pain associated with the microneedle pretreatment and with the application of the PDT using the 100 mm Visual Analog Scale pain grading. Using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the "no pain" anchor and the patient's mark, providing a range of scores from 0-100. A higher score indicates greater pain intensity. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Difference in the Percentage of Complete Clearance of the Actinic Keratoses | Baseline, 2 Months | Percentage of AK Clearance | MEAN | |
| SECONDARY | Visual Analog Pain Scale | Immediately Post-Treatment | Millimeters | MEAN |
Source ClinicalTrials.gov
Results by group12
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Difference in the Percentage of Complete Clearance of the Actinic Keratoses | 10-minute Incubation With Microneedle Roller | 43 | Standard Error 13 | Percentage of AK Clearance | |
| Difference in the Percentage of Complete Clearance of the Actinic Keratoses | 20-minute Incubation With Microneedle Roller | 76 | Standard Error 3.9 | Percentage of AK Clearance | |
| Difference in the Percentage of Complete Clearance of the Actinic Keratoses | 10-minute Incubation With Sham Microneedles | 38 | Standard Error 8.1 | Percentage of AK Clearance | |
| Difference in the Percentage of Complete Clearance of the Actinic Keratoses | 20-minute Incubation With Sham Microneedles | 58 | Standard Error 5.7 | Percentage of AK Clearance | |
| Visual Analog Pain Scale | Pain_microneedle: 10-minute Incubation With Microneedle Roller | 1.4 | Standard Error .5 | Millimeters | |
| Visual Analog Pain Scale | Pain_microneedle: 20-minute Incubation With Microneedle Roller | 1.3 | Standard Error .4 | Millimeters | |
| Visual Analog Pain Scale | Pain_microneedle: 10-minute Incubation With Microneedle Sham | .3 | Standard Error .2 | Millimeters | |
| Visual Analog Pain Scale | Pain_microneedle: 20-minute Incubation With Microneedle Sham | .3 | Standard Error .2 | Millimeters | |
| Visual Analog Pain Scale | Pain_PDT: 10-minute Incubation With Microneedle Sham | 0.3 | Standard Error 0.2 | Millimeters | |
| Visual Analog Pain Scale | Pain_PDT: 10-minute Incubation With Microneedle Roller | .5 | Standard Error .2 | Millimeters |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | 10-minute Incubation With Microneedle Roller & Sham | 16 | |
| Overall Study | STARTED | 20-minute Incubation With Microneedle Roller | 16 | |
| Overall Study | COMPLETED | 10-minute Incubation With Microneedle Roller & Sham | 16 | |
| Overall Study | COMPLETED | 20-minute Incubation With Microneedle Roller | 15 | |
| Overall Study | NOT COMPLETED | 10-minute Incubation With Microneedle Roller & Sham | 0 | |
| Overall Study | NOT COMPLETED | 20-minute Incubation With Microneedle Roller | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | 10-minute Incubation With Microneedle Roller & Sham | 0 | 16 |
| Total, all-cause mortality | 20-minute Incubation With Microneedle Roller & Sham | 0 | 16 |
| Total, other adverse events | 10-minute Incubation With Microneedle Roller & Sham | 0 | 16 |
| Total, other adverse events | 20-minute Incubation With Microneedle Roller & Sham | 0 | 16 |
| Total, serious adverse events | 10-minute Incubation With Microneedle Roller & Sham | 0 | 16 |
| Total, serious adverse events | 20-minute Incubation With Microneedle Roller & Sham | 0 | 16 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 28514458 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| 10-minute Incubation With Microneedle Roller & Sham vs 20-minute Incubation With Microneedle Roller & Sham: deaths from any cause | Trial comparisons |
| 10-minute Incubation With Microneedle Roller & Sham vs 20-minute Incubation With Microneedle Roller & Sham: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02594644
GET https://conductscience.org/api/trials/v1/NCT02594644/registered