Trial · NCT02625181
Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis
NCT02625181, Not applicable, Completed, Vanderbilt University; results first posted 2019-03-07
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis. Trials, record NCT02625181. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02625181
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis
- NCT number
- NCT02625181
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 27,034 participants, actual
- Lead sponsor
- Vanderbilt University
- Conditions
- Postoperative Nausea and Vomiting
- Interventions
Automated recommendation at the start of the case, Automated notification at the start of surgery, Preoperative recommendations: by email, Automated notification at the end of surgery, Anesthesia Information Management System (AIMS), Perioperative Data Warehouse (PDW), General anesthesia, Elective surgery, Propofol, Sevoflurane, Isoflurane, Desflurane, Scopolamine, Droperidol, Haloperidol, Dexamethasone, Promethazine, Meclizine, Aprepitant, Metoclopramide, Fentanyl, Sufentanil, Alfentanil, Remifentanil, Morphine, Meperidine, Hydromorphone, Methadone, Oxycodone, Oxymorphone, Hydrocodone, Ketamine, Ondansetron, Granisetron, Dolasetron mesylate, Palonosetron, Tropisetron, Ramosetron
- First posted
- 2015-12-09
- Last updated
- 2019-03-07
- Results first posted
- 2019-03-07
- Limitations and caveats
We were unable to complete analysis of hyperlink data for PONV recommendations as planned because the data were not archived as intended. We were unable to include University of Washington as a collaborative site due to technical differences.
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Adherence to PONV Guidelines | A specific time frame on the day of surgery: the start of admission at the holding room to the end of the anesthetic case | PONV guideline adherence: percentage of patients who received the exact number of prophylactic interventions for PONV that were recommended by the decision support. |
| Secondary | PONV Incidence: Number of Participants With Postoperative Nausea and Vomiting | PACU recovery period | The occurrence of PONV, as defined by the administration of antiemetics in the PACU between admission to PACU and discharge from PACU. |
| Secondary | The Number of Prophylactic Interventions for PONV | A specific time frame on the day of surgery: from the start of admission at the holding room to the end of the anesthetic case | the absolute number of prophylactic interventions applied between the admission of the patient in the holding room until admission to the PACU. |
| Secondary | Time to Discharge From the Postanesthesia Care Unit (PACU) | A specific time frame on the day of surgery: from the start of admission to the PACU to discharge from the PACU | This is the number of minutes from admission to the PACU until discharge, assessed up to 2 days |
Source ClinicalTrials.gov
Outcomes4
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Adherence to PONV Guidelines | A specific time frame on the day of surgery: the start of admission at the holding room to the end of the anesthetic case | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | PONV Incidence: Number of Participants With Postoperative Nausea and Vomiting | PACU recovery period | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | The Number of Prophylactic Interventions for PONV | A specific time frame on the day of surgery: from the start of admission at the holding room to the end of the anesthetic case | prophylactic antiemetics administered | MEAN | |
| SECONDARY | Time to Discharge From the Postanesthesia Care Unit (PACU) | A specific time frame on the day of surgery: from the start of admission to the PACU to discharge from the PACU | minutes | MEAN |
Source ClinicalTrials.gov
Results by group12
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Adherence to PONV Guidelines | Baseline Measurement | 666 | Participants | ||
| Adherence to PONV Guidelines | CDS Email Recommendations | 5260 | Participants | ||
| Adherence to PONV Guidelines | CDS Email + Real TIme Recommenations | 5863 | Participants | ||
| PONV Incidence: Number of Participants With Postoperative Nausea and Vomiting | Baseline Measurement | 139 | Participants | ||
| PONV Incidence: Number of Participants With Postoperative Nausea and Vomiting | CDS Email Recommendations | 1323 | Participants | ||
| PONV Incidence: Number of Participants With Postoperative Nausea and Vomiting | CDS Email + Real TIme Recommenations | 1343 | Participants | ||
| The Number of Prophylactic Interventions for PONV | Baseline Measurement | 2.196 | Standard Deviation 0.932 | prophylactic antiemetics administered | |
| The Number of Prophylactic Interventions for PONV | CDS Email Recommendations | 2.176 | Standard Deviation 0.988 | prophylactic antiemetics administered | |
| The Number of Prophylactic Interventions for PONV | CDS Email + Real TIme Recommenations | 2.129 | Standard Deviation 0.977 | prophylactic antiemetics administered | |
| Time to Discharge From the Postanesthesia Care Unit (PACU) | Baseline Measurement | 266 | Standard Deviation 374 | minutes |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 results by groupParticipant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Baseline Measurement | 1,518 | |
| Overall Study | STARTED | CDS Email Recommendations | 12,809 | |
| Overall Study | STARTED | CDS Email + Real TIme Recommenations | 12,707 | |
| Overall Study | COMPLETED | Baseline Measurement | 1,518 | |
| Overall Study | COMPLETED | CDS Email Recommendations | 12,809 | |
| Overall Study | COMPLETED | CDS Email + Real TIme Recommenations | 12,707 | |
| Overall Study | NOT COMPLETED | Baseline Measurement | 0 | |
| Overall Study | NOT COMPLETED | CDS Email Recommendations | 0 | |
| Overall Study | NOT COMPLETED | CDS Email + Real TIme Recommenations | 0 |
Source ClinicalTrials.gov
Adverse events3
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Mortality - Baseline | Investigations | PONV Clinical Decision Support System | 7 | 1,518 | 7 |
| serious | Mortality - CDS Email Recommendations | Investigations | PONV Clinical Decision Support System | 43 | 12,809 | 43 |
| serious | Mortality - CDS Email + Real Time Recommendations | Investigations | PONV Clinical Decision Support System | 40 | 12,707 | 40 |
Source ClinicalTrials.gov
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | PONV Clinical Decision Support System | 90 | 27,034 |
| Total, other adverse events | PONV Clinical Decision Support System | 0 | 27,034 |
| Total, serious adverse events | PONV Clinical Decision Support System | 90 | 27,034 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02625181
GET https://conductscience.org/api/trials/v1/NCT02625181/registered