Trial · NCT02638467
Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy
NCT02638467, Phase 2, Completed, University of Milano Bicocca
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy. Trials, record NCT02638467. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02638467
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Allogeneic Stem Cell Transplantation in Chronic Myeloid Leukemia Failing TKIs Therapy
- NCT number
- NCT02638467
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 2 participants, actual
- Lead sponsor
- University of Milano Bicocca
- Conditions
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Interventions
- Bosutinib, Bone Marrow Transplant, Bone Marrow cells
- First posted
- 2015-12-23
- Last updated
- 2020-11-05
Source ClinicalTrials.gov
Registered outcomes14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Efficacy as assessed by the percentage of patients with Complete Cytogenetic Response (CCyR) | 12 months | The percentage of patients with Complete Cytogenetic Response (CCyR) will be calculated as the complement to the percentage of failures on the total number of patients treated, where failure includes the following events: no engraftment, death within 12 months, no CCyR at 12 months. |
| Secondary | Overall Survival | 12 months | |
| Secondary | Percentage of patients with engraftment | 12 months | |
| Secondary | percentage of patients with complete chimerism (95%) | Day +28, +56 and +100 | |
| Secondary | Evaluation of Major Cytogenetic Response (MCyR) | 12 months | Major Cytogenetic Response (MCyR) is \< 36% Ph+ metaphases |
| Secondary | Evaluation of molecular responses | 12 months | Molecular response is defined * Complete: if there is undetectable BCR-ABL transcript * Major: if ratio BCR/ABL \<= 0.1% on International Scale |
| Secondary | Relapse incidence (RI) | 12 months | |
| Secondary | Incidence of non-relapse mortality (NRM) | Within day +28 and +360 | |
| Secondary | Incidence and severity of acute and chronic graft vs. host disease (GvHD) | 12 months | |
| Secondary | Quality of Life (QoL) | 12 months | Evaluation of QoL with EQ-5D-5L (Italian - Version 2) and FACT-Leu (Italian -Version 4) |
1 to 10 of 14Source ClinicalTrials.gov
See all 14 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02638467
GET https://conductscience.org/api/trials/v1/NCT02638467/registered