Trial · NCT02674412
Buspirone for Functional Dysphagia
NCT02674412, Not applicable, Completed, The Cleveland Clinic; results first posted 2018-08-10
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Buspirone for Functional Dysphagia. Trials, record NCT02674412. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02674412
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Buspirone for Functional Dysphagia
- NCT number
- NCT02674412
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 10 participants, actual
- Lead sponsor
- The Cleveland Clinic
- Conditions
- Functional Dysphagia, Ineffective Esophageal Motility
- Interventions
- Buspirone, Placebo
- First posted
- 2016-02-04
- Last updated
- 2018-08-10
- Results first posted
- 2018-08-10
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Distal Contractile Index (DCI) on High Resolution Esophageal Manometry | Change in the score from Baseline to 14 days | DCI is a measure of the strength of muscle contractions in the esophagus while swallowing. It is measured in mm Hg, and values greater than 450mm Hg are considered Normal. |
| Secondary | Change in Gastroesophageal Reflux Disease - Health Related Quality Questionnaire Score | Change in the score from Baseline to 14 days | A 16-question questionnaire with a score range from 0 to 80, with higher scores indicating worse outcomes (more severe symptoms of GERD). |
| Secondary | Change in Percentage of Normal Swallows Recorded in a Series of 10 Measured Swallows. | 14 days | A normal swallow is defined as a swallow with a Distal Contractile Index greater than 450mm Hg |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Distal Contractile Index (DCI) on High Resolution Esophageal Manometry | Change in the score from Baseline to 14 days | mm Hg | MEAN | |
| SECONDARY | Change in Gastroesophageal Reflux Disease - Health Related Quality Questionnaire Score | Change in the score from Baseline to 14 days | Scores on a scale | MEAN | |
| SECONDARY | Change in Percentage of Normal Swallows Recorded in a Series of 10 Measured Swallows. | 14 days | percentage of swallows | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Distal Contractile Index (DCI) on High Resolution Esophageal Manometry | Buspirone | 241.9 | Standard Deviation 771.7 | mm Hg | |
| Change in Distal Contractile Index (DCI) on High Resolution Esophageal Manometry | Placebo | 340.4 | Standard Deviation 761.7 | mm Hg | |
| Change in Gastroesophageal Reflux Disease - Health Related Quality Questionnaire Score | Buspirone | -4.1 | Standard Deviation 22.2 | Scores on a scale | |
| Change in Gastroesophageal Reflux Disease - Health Related Quality Questionnaire Score | Placebo | -10.2 | Standard Deviation 16.6 | Scores on a scale | |
| Change in Percentage of Normal Swallows Recorded in a Series of 10 Measured Swallows. | Buspirone | 15 | Standard Deviation 37 | percentage of swallows | |
| Change in Percentage of Normal Swallows Recorded in a Series of 10 Measured Swallows. | Placebo | 20 | Standard Deviation 39 | percentage of swallows |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Buspirone Then Placebo | 5 | |
| Overall Study | STARTED | Placebo Then Buspirone | 5 | |
| Overall Study | COMPLETED | Buspirone Then Placebo | 5 | |
| Overall Study | COMPLETED | Placebo Then Buspirone | 5 | |
| Overall Study | NOT COMPLETED | Buspirone Then Placebo | 0 | |
| Overall Study | NOT COMPLETED | Placebo Then Buspirone | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Buspirone | 0 | 10 |
| Total, all-cause mortality | Placebo | 0 | 10 |
| Total, other adverse events | Buspirone | 0 | 10 |
| Total, other adverse events | Placebo | 0 | 10 |
| Total, serious adverse events | Buspirone | 0 | 10 |
| Total, serious adverse events | Placebo | 0 | 10 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Buspirone vs Placebo: deaths from any cause | Trial comparisons |
| Buspirone vs Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02674412
GET https://conductscience.org/api/trials/v1/NCT02674412/registered