Neurologic Injury Following Aortic Arch Replacement
NCT02750423, Not applicable, Completed, Emory University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Neurologic Injury Following Aortic Arch Replacement | ClinicalTrials.gov |
| NCT number | NCT02750423 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 20 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Emory University | ClinicalTrials.gov |
| Conditions | Aortic Arch Replacement, Hemi Arch Replacement | ClinicalTrials.gov |
| Interventions | DHCA+RCP, MHCA + SACP | ClinicalTrials.gov |
| First posted | 2016-04-25 | ClinicalTrials.gov |
| Last updated | 2018-03-30 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Incidence of Stroke | Duration of Study (Up to 180 days) | The number of participants with a new focal neurologic deficit lasting greater than 24 hours that is confirmed by radiographic evidence of infarction. | ClinicalTrials.gov |
| Primary | Incidence of Transient Ischemic Attack (TIA) | Duration of Study (Up to 180 days) | The number of participants with a new focal neurologic symptom lasting less than 24 hours without radiographic evidence of infarction. | ClinicalTrials.gov |
| Primary | Rate of Neurologic Injury assessed by Magnetic Resonance Imaging (MRI) | Duration of Study (Up to 180 days) | The number of participants with evidence of neurologic injury assessed by MRI. | ClinicalTrials.gov |
| Primary | Change in Verbal Memory Test Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The verbal memory test measures how many words participants can keep in short term memory at once. A higher score indicates better short term memory. | ClinicalTrials.gov |
| Primary | Change in Visual Memory Test Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The visual memory test measures how many items a participant can keep in short term memory at once. A higher score indicates better short term memory. | ClinicalTrials.gov |
| Primary | Change in Finger Tapping Test Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The finger-tapping test (FTT) is a neuropsychological test that examines motor functioning, specifically, motor speed and lateralized coordination. During administration, the participant's palm should be immobile and flat on the board, with fingers extended, and the index finder placed on the counting device. One hand at a time, participants tap their index finger on the lever as quickly as possible within a 10-s time interval, in order to increase the number on the counting device with each tap. | ClinicalTrials.gov |
| Primary | Change in Symbol Digit Coding Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The Digit symbol substitution test (DSST) is a neuropsychological test sensitive to brain damage, dementia, age and depression. It consists of nine digit-symbol pairs followed by a list of digits.Under each digit the participant should write down the corresponding symbol as fast as possible. The number of correct symbols within the allowed time is measured. | ClinicalTrials.gov |
| Primary | Change in Stroop Test Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The Stroop effect is a demonstration of interference in the reaction time of a task. Participants will be asked the name of a color printed in a color not denoted by the name. Naming the color of the word takes longer and is more prone to errors than when the color of the ink matches the name of the color. | ClinicalTrials.gov |
| Primary | Change in Shifting Attention Test Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The Shifting Attention Test measures a participant's executive functions (rules, categories, rapid decision making) or their ability to shift from one instruction set to another quickly and accurately. | ClinicalTrials.gov |
| Primary | Change in Continuous Performance Test Score | Post Operative Visit Day 1, Post Operative Visit Day 180 | The continuous performance test measures a participant's sustained and selective attention. Sustained attention is the ability to maintain a consistent focus on some continuous activity or stimuli, and is associated with impulsivity. Selective attention is the ability to focus on relevant stimuli and ignore competing stimuli. This skill is associated with distractibility.\[1\] | ClinicalTrials.gov |
| Secondary | Incidence of Temporary Neurologic Deficit (TND) | Duration of Study (Up to 180 days) | The number of participants with a reversible, non-focal clinical neurologic injury without radiographic evidence of infarction. | ClinicalTrials.gov |
| Secondary | Change in Serum S-100 Levels | Post Operative Visit Day 1, Post Operative Visit Day 180 | Serum S-100 is a biomarker for neurologic injury found in blood serum. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Continuous Performance Test | Primary outcome | ConductCognition |
| Finger Tapping Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)