Trial · NCT02758431
Cardiovascular Outcomes of Low Testosterone
NCT02758431, Not applicable, Completed, University of Colorado, Denver
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cardiovascular Outcomes of Low Testosterone. Trials, record NCT02758431. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02758431
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cardiovascular Outcomes of Low Testosterone
- NCT number
- NCT02758431
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 232 participants, actual
- Lead sponsor
- University of Colorado, Denver
- Conditions
- Hypogonadism
- Interventions
- Acyline, Placebo Gel, Placebo Tablet, Testosterone Gel, Arimidex
- First posted
- 2016-05-02
- Last updated
- 2024-10-10
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Endothelial function | Change from baseline at 28 days | Brachial artery flow-mediated dilation, and EndoPAT™ |
| Primary | Carotid artery compliance | Change from baseline at 28 days | Carotid artery compliance and beta stiffness index |
| Primary | Arterial stiffness | Change from baseline at 28 days | Pulse-wave velocity |
| Primary | Left ventricular diastolic function | Change from baseline at 28 days | Measured via Cardiac Echo |
| Secondary | NADPH oxidase | Change from baseline at 28 days | Oxidative stress marker measured in endothelial cells |
| Secondary | Nitrotyrosine | Change from baseline at 28 days | Measured in endothelial cells |
| Secondary | MnSOD | Change from baseline at 28 days | Mitochondrial superoxide dismutase measured in endothelial cells |
| Secondary | eNOS | Change from baseline at 28 days | Endothelial nitric oxide synthase (eNOS) measured in endothelial cell |
| Secondary | COX IV | Change from baseline at 28 days | Marker of mitochondrial function measured in PBMCs |
| Secondary | Mitochondrial RCR | Change from baseline at 28 days | Mitochondrial respiration measured via Oroboros O2K |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants2
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| R01AG049762 | Cardiovascular Consequences of Hypogonadism in Men | MOREAU, KERRIE | UNIVERSITY OF COLORADO DENVER | NATIONAL INSTITUTE ON AGING | 2016 to 2020 | NIH RePORTER |
| UL1TR001082 | Colorado Clinical and Translational Sciences Institute | SOKOL, RONALD J. | UNIVERSITY OF COLORADO DENVER | NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES | 2013 to 2017 | NIH RePORTER |
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02758431
GET https://conductscience.org/api/trials/v1/NCT02758431/registered