Trial · NCT02811289
Pharmacological Activation of Brown Adipose Tissue Metabolism
NCT02811289, Not applicable, Completed, Université de Sherbrooke
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Pharmacological Activation of Brown Adipose Tissue Metabolism. Trials, record NCT02811289. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02811289
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pharmacological Activation of Brown Adipose Tissue Metabolism
- NCT number
- NCT02811289
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 22 participants, actual
- Lead sponsor
- Université de Sherbrooke
- Conditions
- Type 2 Diabetes
- Interventions
- Mirbetriq (Mirabegron), cold exposure, injection of 18FDG, injection of 11C-acetate, [3-3H]-glucose, [U-13C]-palmitate, 2H-Glycerol
- First posted
- 2016-06-23
- Last updated
- 2018-08-22
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | BAT net glucose uptake | 2 years | will be assessed using i.v. injection of 18FDG with sequential dynamic PET/CT scanning. |
| Primary | BAT oxidative metabolism | 2 years | will be determined using i.v. injection of 11C-acetate during dynamic PET/CT scanning |
| Primary | BAT volume of metabolic activity | 2 years | will be determined using a total body CT (16 mA) followed by a PET acquisition. |
| Primary | whole body organ glucose partitioning | 2 years | will be determined using a total body CT (16 mA) followed by a PET acquisition be determined using a total body CT (16 mA) followed by a PET acquisition |
| Secondary | lipolysis rate | 2 years | will be measured using i.v. administration of \[13C\]-palmitate and \[2H\]-glycerol, using steele's non steady state equations |
| Secondary | Glucose appearance rate | 2 years | will be determined using \[3-3H\]-glucose |
| Secondary | Energy expenditure | 2 years | will be determined by indirect calorimetry from VO2 and VCO2 (Vmax29n, Sensormedics) |
| Secondary | Insulin sensitivity | 2 years | will be determined using the HOMA-IR (based on fasting insulin and glucose levels) |
| Secondary | Insulin secretion rate | 2 years | will be assessed using deconvolution of plasma C-peptide with standard C-peptide kinetic parameters |
| Secondary | β-cell function | 2 years | will be assessed by calculation of the disposition index (DI) that is insulin secretion in response to the ambient insulin sensitivity. |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 32755608 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02811289
GET https://conductscience.org/api/trials/v1/NCT02811289/registered