Trial · NCT02859727
Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI
NCT02859727, Phase 2, Phase 3, Terminated, Pharming Technologies B.V.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI. Trials, record NCT02859727. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02859727
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Extension to the Study of Efficacy of CDZ173 in Patients With APDS/PASLI
- NCT number
- NCT02859727
- Status
- Terminated
- Phases
- Phase 2, Phase 3
- Enrollment
- 37 participants, actual
- Lead sponsor
- Pharming Technologies B.V.
- Conditions
- Activated PI3Kdelta Syndrome (APDS); PASLI Disease
- Interventions
- CDZ173
- First posted
- 2016-08-09
- Last updated
- 2026-03-30
- Other registries' IDs
- eudract:2016-000468-41
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | To Evaluate the Number of Participants With (S)AEs During Treatment With CDZ173 | 6 years 3 months | Number of participants with adverse events reported, including serious adverse events |
| Secondary | To Evaluate the Long Term Efficacy of CDZ173 Using SF-36 General Health Score | At baseline, after 1 year, after 3 years, after 4 years and after 5 years of study participation | SF-36 (Short Form 36) Survey general health score per participant reported for duration of particpation in study. Scores are reported on a scale of 0 - 100. All items are scored so that a high score defines a more favorable health state. |
| Other | Responder Analysis Soluble Protein Biomarkers - naïve B Cells | up to 252 days | Responder analysis soluble protein biomarkers - Change in naïve b cells from baseline up to Day 252 |
| Other | Sum of Product of Diameters (SPD) of Index Lesions | Baseline and D252 | Participants were scanned through MRI or CT imaging |
| Other | Spleen Organ Evaluation - Volume in mm3 | Baseline and D252 | Participants were scanned through MRI or CT |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02859727
GET https://conductscience.org/api/trials/v1/NCT02859727/registered