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Trial · NCT02883049

Results by group24

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
DFS of Non-DS HR Post-induction Patients Receiving Intrathecal (IT) Methotrexate (MTX) Compared With Patients Receiving Intrathecal Triple Therapy (ITT) on a Modified Berlin-Frankfurt-Munster (MBFM) Interim Maintenance High-dose Methotrexate Backbone
Non-DS HR B-ALL Arm A92.4895% Confidence Interval 90.7 to 94.3Percentage of patients
DFS of Non-DS HR Post-induction Patients Receiving Intrathecal (IT) Methotrexate (MTX) Compared With Patients Receiving Intrathecal Triple Therapy (ITT) on a Modified Berlin-Frankfurt-Munster (MBFM) Interim Maintenance High-dose Methotrexate Backbone
Non-DS HR B-ALL Arm B92.3395% Confidence Interval 90.5 to 94.2Percentage of patients
DFS of Non-DS VHR Post-Induction Patients Who Receive a Modified MBFM-IMHDM Regimen That Contains a Second IM (Control Arm) Compared to Patients Receive the Cyclophosphamide + Etoposide Containing Regimen (Experimental Arm 1)
Non-DS VHR B-ALL Control Arm77.1195% Confidence Interval 72.4 to 81.8Percentage of patients
DFS of Non-DS VHR Post-Induction Patients Who Receive a Modified MBFM-IMHDM Regimen That Contains a Second IM (Control Arm) Compared to Patients Receive the Cyclophosphamide + Etoposide Containing Regimen (Experimental Arm 1)
Non-DS VHR B-ALL Exp Arm176.7595% Confidence Interval 72.8 to 80.7Percentage of patients
Toxicity and Tolerability of Post-induction Age-adjusted ITT Compared to Age-adjusted IT MTX in Children With HR B-ALLNon-DS HR B-ALL Arm A62.4495% Confidence Interval 59.2 to 65.7Percentage of patients
Toxicity and Tolerability of Post-induction Age-adjusted ITT Compared to Age-adjusted IT MTX in Children With HR B-ALLNon-DS HR B-ALL Arm B63.3995% Confidence Interval 60.2 to 66.6Percentage of patients
Toxicity and Tolerability of Experimental Arm 1 and Control Arm in Patients With VHR B-ALLNon-DS VHR B-ALL Control Arm66.2795% Confidence Interval 61.2 to 71.3Percentage of patients
Toxicity and Tolerability of Experimental Arm 1 and Control Arm in Patients With VHR B-ALLNon-DS VHR B-ALL Exp Arm173.1695% Confidence Interval 69.2 to 77.1Percentage of patients
Induction Mortality in Patients With DS and HR B-ALL Treated With Modified InductionDS HR B-ALL (Induction)3.5795% Confidence Interval 1.1 to 6.0Percentage of patients
5-year DFS in Patients With Down Syndrome (DS) and HR B-ALL Treated With Modified Induction and Post-Induction Therapy Regimen With MBFM-IMIDMDS HR B-ALL71.7895% Confidence Interval 65.7 to 77.8Percentage of patients
DFS for Children and Young Adults With Ph-like B-ALL and a Predicted Tyrosine Kinase Inhibitor (TKI)-Sensitive Mutation Treated With Dasatinib Plus MBFM-IMHDMNon-DS Ph-like Pred TKI Sensitive Kinase Dasatinib Arm55.5695% Confidence Interval 32.6 to 78.5Percentage of patients
Toxicity and Tolerability of MBFM-interim Maintenance Intermediate Dose Methotrexate (IMIDM) in Children With Down SyndromeDS HR B-ALL5095% Confidence Interval 43.6 to 56.4Percentage of patients
Overall Survival (OS) Rate for HR B-ALL Patients, Overall and by Randomized ArmNon-DS HR B-ALL Overall96.6595% Confidence Interval 95.8 to 97.5Percentage of patients
Overall Survival (OS) Rate for HR B-ALL Patients, Overall and by Randomized ArmNon-DS HR B-ALL Arm A97.0595% Confidence Interval 95.9 to 98.2Percentage of patients
Overall Survival (OS) Rate for HR B-ALL Patients, Overall and by Randomized ArmNon-DS HR B-ALL Arm B96.2595% Confidence Interval 94.9 to 97.6Percentage of patients
Overall Survival (OS) Rate for VHR B-ALL Patients, Overall and by Randomized Arm.Non-DS VHR B-ALL Overall87.8795% Confidence Interval 85.6 to 90.1Percentage of patients
Overall Survival (OS) Rate for VHR B-ALL Patients, Overall and by Randomized Arm.Non-DS VHR B-ALL Control Arm87.3195% Confidence Interval 83.6 to 91.1Percentage of patients
Overall Survival (OS) Rate for VHR B-ALL Patients, Overall and by Randomized Arm.Non-DS VHR B-ALL Experimental Arm 188.5095% Confidence Interval 85.5 to 91.5Percentage of patients
Incidence of Osteonecrosis (ON) Defined by Magnetic Resonance (MR) Imaging in Children, Adolescents, and Young Adults 10 Years of Age and GreaterHR and VHR B-ALL Patients (10 Years or Older)2595% Confidence Interval 19.8 to 30.2Percentage of patients
The Prevalence of Cognitive Deficits Measured by CogState (Domain: Working Memory), in Children (Ages 6 to < 13 Years) With HR- and VHR B-ALL at 1 Year Off TherapyHR and VHR B-ALL Patients (6 to <13 Years Old)19.11percentage of participants

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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