Cognitive Training in Parkinson Study
NCT02920632, Not applicable, Completed, Amsterdam UMC, location VUmc; results first posted 2024-09-19
Trial 12
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Cognitive Training in Parkinson Study | ClinicalTrials.gov |
| NCT number | NCT02920632 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 167 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Amsterdam UMC, location VUmc | ClinicalTrials.gov |
| Conditions | Parkinson Disease, Impaired Cognition, Alteration in Cognition | ClinicalTrials.gov |
| Interventions | Online cognitive training 1, Online cognitive training 2 | ClinicalTrials.gov |
| First posted | 2016-09-30 | ClinicalTrials.gov |
| Last updated | 2024-09-19 | ClinicalTrials.gov |
| Results first posted | 2024-09-19 | ClinicalTrials.gov |
| Limitations and caveats | Sample size fell short of the intended statistical power: the initial sample size calculation was based on a within-between interaction of a repeated-measures ANOVA (corrected for pre-post assessment correlation r=.6) based on an effect size f=0.12 of CT on global cognitive function (Leung et al 2015). After trial completion we discovered this sample size is insufficient to detect the expected effect on global cognition due to obscurity in effect size parameter definition in G\*Power. | ClinicalTrials.gov |
Registered outcomes 42
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Accuracy on the Tower of London Task | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Change in executive function after eight weeks of cognitive training as measured by percentage correct on the Tower of London task. Accuracy is measured in percentage correct (%, range 0-100, higher is considered better). | ClinicalTrials.gov |
| Secondary | Total Score on Parkinson's Disease Cognitive Functional Rating Scale | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Score on subjective cognitive complaints after eight weeks of cognitive training, measured with the Parkinson's disease Cognitive Functional Rating Scale (PD-CFRS), with score range \[0-24\], where higher scores indicate more severe subjective cognitive complaints. | ClinicalTrials.gov |
| Secondary | Total Score on Cognitive Failures Questionnaire | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Score on subjective cognitive complaints after eight weeks of cognitive training (T0 to T1), measured by the Cognitive failures questionnaire (CFQ), a questionnaire with range \[0-100\] where a higher score indicates more severe subjective cognitive complaints. | ClinicalTrials.gov |
| Secondary | Reaction Time on the Tower of London Task | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Change on Executive function from T0 to T1, measured with the average reaction time on the Tower of London task over all trials. Reaction time is measured in seconds, where higher reaction time is considered worse. | ClinicalTrials.gov |
| Secondary | Performance on the Controlled Oral Word Association Test | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Executive functions CHANGE after eight weeks of cognitive training (T0 to T1), measured with the Controlled Oral Word Association Test (Letter fluency). Minimum score: 0, there is no maximum score. A higher score indicates better performance. | ClinicalTrials.gov |
| Secondary | Performance on Tower of London Accuracy at Six-months Follow-up | Six months after training completion (T2) | Persistence of cognitive training effect on executive functions measured with the accuracy on the Tower of London task six-month after completion of the intervention. Accuracy is measured with mean percentage correct over 100 trials, where a higher percentage correct reflects better cognitive function. | ClinicalTrials.gov |
| Secondary | Performance on Tower of London Accuracy at One-year Follow-up | One year after completion of intervention (T3, "Follow-up 2") | Persistence of cognitive training effect on executive functions measured with the accuracy on the Tower of London task one year after completion of the intervention. Accuracy is measured with mean percentage correct over 100 trials, where a higher percentage correct reflects better cognitive function. | ClinicalTrials.gov |
| Secondary | Performance on Tower of London Accuracy at Two-year Follow-up | Two years after completion of the intervention (T4) | Persistence of cognitive training effect on executive functions measured with the accuracy on the Tower of London task two year after completion of the intervention. Accuracy is measured with mean percentage correct over 100 trials, where a higher percentage correct reflects better cognitive function. | ClinicalTrials.gov |
| Secondary | Conversion to Mild Cognitive Impairment or Dementia at One-year Follow-up | One year after completion of the intervention (T3) | Incidence of conversion of cognitive status at one-year follow-up with respect to the cognitive status at baseline (T0). Cognitive status is defined as cognitively normal (NC), mild cognitive impairment (MCI, according to cognitive aspects of level II MDS criteria), or dementia (according to cognitive aspects of MDS criteria for probable PD dementia). Conversion was defined as -1: conversion to a worse classification (ie, NC to MCI, NC to dementia or MCI to dementia), 0: no change, or 1: conversion to a better classification (ie, dementia to NC, MCI to NC, dementia to MCI). | ClinicalTrials.gov |
| Secondary | Performance on the Stroop Color-Word Test, Card I | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Processing speed change after eight weeks of cognitive training, measured with the Stroop Color Word Test (word-reading), where a higher time to completion indicates worse cognitive function. | ClinicalTrials.gov |
| Secondary | Performance on the Stroop Color-Word Test, Card III | Baseline (T0, "Pre-intervention") to eight weeks (T1, "Post-intervention") | Executive function CHANGE after eight weeks of cognitive training, measured with the Stroop Color Word Test (card III, color-word interference), where a higher time to completion indicates worse cognitive function. | ClinicalTrials.gov |
| Secondary | Conversion of Cognitive Status at Two-year Follow-up | Two year after completion of the intervention (T3) | Count of conversion of cognitive status at two-year follow-up with respect to the cognitive status at baseline (T0). Cognitive status is defined as cognitively normal (NC), mild cognitive impairment (MCI, according to cognitive aspects of level II MDS criteria), or dementia (according to cognitive aspects of MDS criteria for probable PD dementia). Conversion was defined as -1: conversion to a worse classification (ie, NC to MCI, NC to dementia or MCI to dementia), 0: no change, or 1: conversion to a better classification (ie, dementia to NC, MCI to NC, dementia to MCI). | ClinicalTrials.gov |
| Other | Difference Between Parkinson's Disease Patients' Brain Network Topology With or Without Cognitive Impairment, and Healthy Control Subjects. | Pre-intervention (T0) | Participants will be classified to cognitive impairment or no cognitive impairment, and their brain network topology will be compared with healthy subjects. | ClinicalTrials.gov |
| Other | Online Cognitive Training Effect on Brain Network Topology Relative to Healthy Control Group | Eight weeks (T1) | The effect of online cognitive training on brain network topology using resting state fMRI compared with brain network topology of healthy subjects. Healthy subjects will undergo (functional) MRI scanning once. | ClinicalTrials.gov |
| Other | Online Cognitive Training Effect on Brain Activity Measured by Resting State fMRI | Eight weeks (T1) | The effect of online cognitive training on brain activity using resting state fMRI. Regional activity and functional connectivity changes will be assessed after eight weeks of training (T1). | ClinicalTrials.gov |
| Other | Online Cognitive Training Effect on Structural Brain Connectivity Measured by DTI | Eight weeks (T1) | The effect of online cognitive training on structural brain connectivity using DTI. Structural changes will be assessed after eight weeks of training (T1). | ClinicalTrials.gov |
| Other | Online Cognitive Training Effect on Brain Morphology Measured by MRI | Eight weeks (T1) | The effect of online cognitive training on brain morphology using MRI. Structural changes will be assessed after eight weeks of training (T1). | ClinicalTrials.gov |
| Other | Age | Pre-intervention (T0) | Demographic characteristic: age at baseline. | ClinicalTrials.gov |
| Other | Sex | Pre-intervention (T0) | Demographic characteristic: sex. | ClinicalTrials.gov |
| Other | Educational Level | Pre-intervention (T0) | Demographic characteristic: educational level. | ClinicalTrials.gov |
Outcomes 42
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|---|---|---|---|---|---|
| PRIMARY | Accuracy on the Tower of London Task | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | Number analyzed lower due to difficulty understanding the task, or no follow-up assessment in PD group and difficulty understanding the task (n=1) in healthy control group. Healthy control subjects did not undergo an intervention and T1 measurement and scores at T1 are therefore not supplied for this subgroup. | percentage of correct responses | MEAN | ClinicalTrials.gov |
| SECONDARY | Total Score on Parkinson's Disease Cognitive Functional Rating Scale | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | Questionnaire not taken in healthy control group | score on a scale | MEAN | ClinicalTrials.gov |
| SECONDARY | Total Score on Cognitive Failures Questionnaire | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | One participant in Online cognitive training 1 did not fill out the questionnaires. | scores on a scale | MEAN | ClinicalTrials.gov |
| SECONDARY | Reaction Time on the Tower of London Task | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | Number analyzed lower due to difficulty understanding the task (n=7), or no follow-up assessment (n=3) in PD group and difficulty understanding the task (n=1) in healthy control group. Healthy control subjects did not undergo an intervention and T1 measurement and scores at post-intervention are therefore not supplied. | seconds | MEAN | ClinicalTrials.gov |
| SECONDARY | Performance on the Controlled Oral Word Association Test | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | Three participants dropped out of the study and did not perform the T1 measurement and were subsequently removed from analyses. Healthy control subjects did not perform the second assessment. | total number of words produced | MEAN | ClinicalTrials.gov |
| SECONDARY | Performance on Tower of London Accuracy at Six-months Follow-up | Six months after training completion (T2) | Healthy control subjects did not undergo follow-up assessment. Number of participants analyzed lower than total population due to drop-out at T2 (n=8) and difficulty understanding the task at one of the time-points (n=11) | percentage of correct responses | MEAN | ClinicalTrials.gov |
| SECONDARY | Performance on Tower of London Accuracy at One-year Follow-up | One year after completion of intervention (T3, Follow-up 2) | Healthy control subjects did not undergo follow-up assessments. Number of participants analyzed differs from total sample due to drop-out (n=12), missed assessment (n=15) and difficulty understanding the task (n=2). | percentage of correct responses | MEAN | ClinicalTrials.gov |
| SECONDARY | Performance on Tower of London Accuracy at Two-year Follow-up | Two years after completion of the intervention (T4) | Healthy control subjects did not undergo follow-up assessemnts. Number of participants analyzed differs from total sample due to drop-out (n=12), missed assessment (n=21) and difficulty understanding the task. | percentage of correct responses | MEAN | ClinicalTrials.gov |
| SECONDARY | Conversion to Mild Cognitive Impairment or Dementia at One-year Follow-up | One year after completion of the intervention (T3) | Healthy control subjects did not undergo follow-up assessments. Number of participants analyzed differs from total population due to drop-out and missed assessment. | participants | NUMBER | ClinicalTrials.gov |
| SECONDARY | Performance on the Stroop Color-Word Test, Card I | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | Three participants dropped out of the study and did not perform the T1 measurement and were subsequently removed from analyses. Healthy control subjects did not perform the second assessment. | time in seconds | MEAN | ClinicalTrials.gov |
| SECONDARY | Performance on the Stroop Color-Word Test, Card III | Baseline (T0, Pre-intervention) to eight weeks (T1, Post-intervention) | Three participants dropped out of the study and did not perform the T1 measurement and one participant did not undergo card III of the Stroop color word test at T1; these participants were subsequently removed from analyses. Healthy control subjects did not perform the second assessment. | time in seconds | MEAN | ClinicalTrials.gov |
| SECONDARY | Conversion of Cognitive Status at Two-year Follow-up | Two year after completion of the intervention (T3) | Healthy control subjects did not undergo follow-up assessments. Number of participants analyzed differs from total population due to drop-out and missed assessment. | participants | NUMBER | ClinicalTrials.gov |
| OTHER_PRE_SPECIFIED | Difference Between Parkinson's Disease Patients' Brain Network Topology With or Without Cognitive Impairment, and Healthy Control Subjects. | Pre-intervention (T0) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Online Cognitive Training Effect on Brain Network Topology Relative to Healthy Control Group | Eight weeks (T1) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Online Cognitive Training Effect on Brain Activity Measured by Resting State fMRI | Eight weeks (T1) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Online Cognitive Training Effect on Structural Brain Connectivity Measured by DTI | Eight weeks (T1) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Online Cognitive Training Effect on Brain Morphology Measured by MRI | Eight weeks (T1) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Age | Pre-intervention (T0) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Sex | Pre-intervention (T0) | ClinicalTrials.gov | |||
| OTHER_PRE_SPECIFIED | Educational Level | Pre-intervention (T0) | ClinicalTrials.gov |
Results by group 51
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|---|---|---|---|---|---|
| Accuracy on the Tower of London Task | Online Cognitive Training 1 | Baseline - T0 | 81.2 | Standard Deviation 9.1 | percentage of correct responses | ClinicalTrials.gov |
| Accuracy on the Tower of London Task | Online Cognitive Training 2 | Baseline - T0 | 82.3 | Standard Deviation 7.9 | percentage of correct responses | ClinicalTrials.gov |
| Accuracy on the Tower of London Task | Healthy Control Subjects | Baseline - T0 | 88.1 | Standard Deviation 5.8 | percentage of correct responses | ClinicalTrials.gov |
| Accuracy on the Tower of London Task | Online Cognitive Training 1 | eight weeks - T1 | 84.0 | Standard Deviation 10.4 | percentage of correct responses | ClinicalTrials.gov |
| Accuracy on the Tower of London Task | Online Cognitive Training 2 | eight weeks - T1 | 84.9 | Standard Deviation 8.2 | percentage of correct responses | ClinicalTrials.gov |
| Total Score on Parkinson's Disease Cognitive Functional Rating Scale | Online Cognitive Training 1 | Baseline - T0 | 8.0 | Standard Deviation 4.0 | score on a scale | ClinicalTrials.gov |
| Total Score on Parkinson's Disease Cognitive Functional Rating Scale | Online Cognitive Training 2 | Baseline - T0 | 9.7 | Standard Deviation 4.7 | score on a scale | ClinicalTrials.gov |
| Total Score on Parkinson's Disease Cognitive Functional Rating Scale | Online Cognitive Training 1 | Eight week - T1 | 6.9 | Standard Deviation 4.3 | score on a scale | ClinicalTrials.gov |
| Total Score on Parkinson's Disease Cognitive Functional Rating Scale | Online Cognitive Training 2 | Eight week - T1 | 8.0 | Standard Deviation 5.1 | score on a scale | ClinicalTrials.gov |
| Total Score on Cognitive Failures Questionnaire | Online Cognitive Training 1 | Baseline - T0 | 38.2 | Standard Deviation 10.6 | scores on a scale | ClinicalTrials.gov |
| Total Score on Cognitive Failures Questionnaire | Online Cognitive Training 2 | Baseline - T0 | 38.5 | Standard Deviation 11.5 | scores on a scale | ClinicalTrials.gov |
| Total Score on Cognitive Failures Questionnaire | Online Cognitive Training 1 | Eight week - T1 | 36.9 | Standard Deviation 10.5 | scores on a scale | ClinicalTrials.gov |
| Total Score on Cognitive Failures Questionnaire | Online Cognitive Training 2 | Eight week - T1 | 38.0 | Standard Deviation 12.7 | scores on a scale | ClinicalTrials.gov |
| Reaction Time on the Tower of London Task | Online Cognitive Training 1 | Baseline - T0 | 12.4 | Standard Deviation 3.2 | seconds | ClinicalTrials.gov |
| Reaction Time on the Tower of London Task | Online Cognitive Training 2 | Baseline - T0 | 12.7 | Standard Deviation 2.7 | seconds | ClinicalTrials.gov |
| Reaction Time on the Tower of London Task | Healthy Control Subjects | Baseline - T0 | 11.2 | Standard Deviation 2.2 | seconds | ClinicalTrials.gov |
| Reaction Time on the Tower of London Task | Online Cognitive Training 1 | Eight weeks - T1 | 11.4 | Standard Deviation 2.9 | seconds | ClinicalTrials.gov |
| Reaction Time on the Tower of London Task | Online Cognitive Training 2 | Eight weeks - T1 | 12.1 | Standard Deviation 2.9 | seconds | ClinicalTrials.gov |
| Performance on the Controlled Oral Word Association Test | Online Cognitive Training 1 | Baseline (T0) | 38.0 | Standard Deviation 10.6 | total number of words produced | ClinicalTrials.gov |
| Performance on the Controlled Oral Word Association Test | Online Cognitive Training 2 | Baseline (T0) | 38.8 | Standard Deviation 11.9 | total number of words produced | ClinicalTrials.gov |
Participant flow 18
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|---|---|---|---|---|
| Overall Study | STARTED | Online Cognitive Training 1 (N=68) | 68 | ClinicalTrials.gov | |
| Overall Study | STARTED | Online Cognitive Training 2 (N=68) | 68 | ClinicalTrials.gov | |
| Overall Study | STARTED | Healthy Control Subjects (N=31) | 31 | ClinicalTrials.gov | |
| Overall Study | T1 (After Training) | Online Cognitive Training 1 (N=68) | 67 | ClinicalTrials.gov | |
| Overall Study | T1 (After Training) | Online Cognitive Training 2 (N=68) | 66 | ClinicalTrials.gov | |
| Overall Study | T1 (After Training) | Healthy Control Subjects (N=31) | 0 | ClinicalTrials.gov | |
| Overall Study | T2 (6-mnth FU) | Online Cognitive Training 1 (N=68) | 64 | ClinicalTrials.gov | |
| Overall Study | T2 (6-mnth FU) | Online Cognitive Training 2 (N=68) | 62 | ClinicalTrials.gov | |
| Overall Study | T2 (6-mnth FU) | Healthy Control Subjects (N=31) | 0 | ClinicalTrials.gov | |
| Overall Study | T3 (1-y FU) | Online Cognitive Training 1 (N=68) | 56 | ClinicalTrials.gov | |
| Overall Study | T3 (1-y FU) | Online Cognitive Training 2 (N=68) | 53 | ClinicalTrials.gov | |
| Overall Study | T3 (1-y FU) | Healthy Control Subjects (N=31) | 0 | ClinicalTrials.gov | |
| Overall Study | COMPLETED | Online Cognitive Training 1 (N=68) | 52 | ClinicalTrials.gov | |
| Overall Study | COMPLETED | Online Cognitive Training 2 (N=68) | 51 | ClinicalTrials.gov | |
| Overall Study | COMPLETED | Healthy Control Subjects (N=31) | 29 | ClinicalTrials.gov | |
| Overall Study | NOT COMPLETED | Online Cognitive Training 1 (N=68) | 16 | ClinicalTrials.gov | |
| Overall Study | NOT COMPLETED | Online Cognitive Training 2 (N=68) | 17 | ClinicalTrials.gov | |
| Overall Study | NOT COMPLETED | Healthy Control Subjects (N=31) | 2 | ClinicalTrials.gov |
Adverse events 30
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|---|---|---|---|---|---|---|
| other | Medical issue related to PD | Nervous system disorders | Online Cognitive Training 1 (N=68) | 1 | 68 | 1 | ClinicalTrials.gov |
| other | Medical issue related to PD | Nervous system disorders | Online Cognitive Training 2 (N=68) | 3 | 68 | 3 | ClinicalTrials.gov |
| other | Medical issue related to PD | Nervous system disorders | Healthy Control Subjects (N=31) | 0 | 31 | 0 | ClinicalTrials.gov |
| other | Training-related adverse event | General disorders | Online Cognitive Training 1 (N=68) | 3 | 68 | 3 | ClinicalTrials.gov |
| other | Training-related adverse event | General disorders | Online Cognitive Training 2 (N=68) | 0 | 68 | 0 | ClinicalTrials.gov |
| other | Training-related adverse event | General disorders | Healthy Control Subjects (N=31) | 0 | 31 | 0 | ClinicalTrials.gov |
| other | Medical issue not PD-related: COVID | Infections and infestations | Online Cognitive Training 1 (N=68) | 0 | 68 | 0 | ClinicalTrials.gov |
| other | Medical issue not PD-related: COVID | Infections and infestations | Online Cognitive Training 2 (N=68) | 1 | 68 | 1 | ClinicalTrials.gov |
| other | Medical issue not PD-related: COVID | Infections and infestations | Healthy Control Subjects (N=31) | 0 | 31 | 0 | ClinicalTrials.gov |
| other | Medical issue other than PD: Ear infection | Infections and infestations | Online Cognitive Training 1 (N=68) | 0 | 68 | 0 | ClinicalTrials.gov |
| other | Medical issue other than PD: Ear infection | Infections and infestations | Online Cognitive Training 2 (N=68) | 1 | 68 | 1 | ClinicalTrials.gov |
| other | Medical issue other than PD: Ear infection | Infections and infestations | Healthy Control Subjects (N=31) | 0 | 31 | 0 | ClinicalTrials.gov |
| other | Medical issue other than PD: injury | Injury, poisoning and procedural complications | Online Cognitive Training 1 (N=68) | 2 | 68 | 2 | ClinicalTrials.gov |
| other | Medical issue other than PD: injury | Injury, poisoning and procedural complications | Online Cognitive Training 2 (N=68) | 3 | 68 | 3 | ClinicalTrials.gov |
| other | Medical issue other than PD: injury | Injury, poisoning and procedural complications | Healthy Control Subjects (N=31) | 0 | 31 | 0 | ClinicalTrials.gov |
| other | Medical issue other than PD: meningioma | Nervous system disorders | Online Cognitive Training 1 (N=68) | 1 | 68 | 2 | ClinicalTrials.gov |
| other | Medical issue other than PD: meningioma | Nervous system disorders | Online Cognitive Training 2 (N=68) | 0 | 68 | 0 | ClinicalTrials.gov |
| other | Medical issue other than PD: meningioma | Nervous system disorders | Healthy Control Subjects (N=31) | 0 | 31 | 0 | ClinicalTrials.gov |
| other | Medical issue other than PD: cerebral infarction | Nervous system disorders | Online Cognitive Training 1 (N=68) | 1 | 68 | 1 | ClinicalTrials.gov |
| other | Medical issue other than PD: cerebral infarction | Nervous system disorders | Online Cognitive Training 2 (N=68) | 1 | 68 | 1 | ClinicalTrials.gov |
Adverse event totals 9
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|---|---|---|---|
| Total, all-cause mortality | Online Cognitive Training 1 (N=68) | 0 | 68 | ClinicalTrials.gov |
| Total, all-cause mortality | Online Cognitive Training 2 (N=68) | 0 | 68 | ClinicalTrials.gov |
| Total, all-cause mortality | Healthy Control Subjects (N=31) | 0 | 31 | ClinicalTrials.gov |
| Total, other adverse events | Online Cognitive Training 1 (N=68) | 9 | 68 | ClinicalTrials.gov |
| Total, other adverse events | Online Cognitive Training 2 (N=68) | 10 | 68 | ClinicalTrials.gov |
| Total, other adverse events | Healthy Control Subjects (N=31) | 0 | 31 | ClinicalTrials.gov |
| Total, serious adverse events | Online Cognitive Training 1 (N=68) | 0 | 68 | ClinicalTrials.gov |
| Total, serious adverse events | Online Cognitive Training 2 (N=68) | 1 | 68 | ClinicalTrials.gov |
| Total, serious adverse events | Healthy Control Subjects (N=31) | 0 | 31 | ClinicalTrials.gov |
Papers 20
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 12633150 | BACKGROUND | PubMed |
| 15480840 | BACKGROUND | PubMed |
| 16247051 | BACKGROUND | PubMed |
| 18217883 | BACKGROUND | PubMed |
| 18307261 | BACKGROUND | PubMed |
| 19733364 | BACKGROUND | PubMed |
| 20826433 | BACKGROUND | PubMed |
| 20838046 | BACKGROUND | PubMed |
| 21427462 | BACKGROUND | PubMed |
| 21440699 | BACKGROUND | PubMed |
| 21661055 | BACKGROUND | PubMed |
| 21971474 | BACKGROUND | PubMed |
| 22365555 | BACKGROUND | PubMed |
| 23426759 | BACKGROUND | PubMed |
| 23985135 | BACKGROUND | PubMed |
| 24639411 | BACKGROUND | PubMed |
| 24867353 | BACKGROUND | PubMed |
| 25534579 | BACKGROUND | PubMed |
| 26519540 | BACKGROUND | PubMed |
| 31366395 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 8
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Tower Planning | Primary outcome | ConductCognition |
| Category Fluency | Other outcome | ConductCognition |
| Complex Figure Copy and Recall | Other outcome | ConductCognition |
| Digit Span Test | Other outcome | ConductCognition |
| Picture Naming Test | Other outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Other outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)