Trial · NCT02961946
Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality
NCT02961946, Phase 4, Completed, Massachusetts General Hospital; results first posted 2019-09-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality. Trials, record NCT02961946. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02961946
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality
- NCT number
- NCT02961946
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 198 participants, actual
- Lead sponsor
- Massachusetts General Hospital
- Conditions
- Coronary Artery Disease
- Interventions
- Nitroglycerin
- First posted
- 2016-11-11
- Last updated
- 2019-09-17
- Results first posted
- 2019-09-17
- Limitations and caveats
- To evaluate coronary diameter change by nitroglycerin administration, non-constrast and contrast ECG-gated images were compared. Measurements avoided areas of visible arteriosclerosis.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Coronary Artery Diameter Change | obtained on the same day (day 0) of nitroglycerine administration (nitroglycerine is administered during the cCTA exam appointment). | Average diameter of coronary arteries at 7 predefined locations in the proximal, mid, and distal segments of the left main, left anterior descending, left circumflex and right coronary artery. Measurements avoid areas of coronary non-calcified and calcified plaques and measured twice for each location. Proximal and distal deviation from original measurements is possible in case of plaque. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Coronary Artery Diameter Change | obtained on the same day (day 0) of nitroglycerine administration (nitroglycerine is administered during the cCTA exam appointment). | Fold change | MEAN |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Coronary Artery Diameter Change | Sublingual Nitroglycerin Spray | 1.14 | 95% Confidence Interval 1.12 to 1.15 | Fold change | |
| Coronary Artery Diameter Change | Sublingual Nitroglycerin Tablet | 1.13 | 95% Confidence Interval 1.09 to 1.16 | Fold change | |
| Coronary Artery Diameter Change | Nitroglycerin Skin Patch | 1.15 | 95% Confidence Interval 1.13 to 1.18 | Fold change |
Source ClinicalTrials.gov
Participant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Sublingual Nitroglycerin Spray | 66 | |
| Overall Study | STARTED | Sublingual Nitroglycerin Tablet | 66 | |
| Overall Study | STARTED | Nitroglycerin Skin Patch | 66 | |
| Overall Study | COMPLETED | Sublingual Nitroglycerin Spray | 66 | |
| Overall Study | COMPLETED | Sublingual Nitroglycerin Tablet | 66 | |
| Overall Study | COMPLETED | Nitroglycerin Skin Patch | 66 | |
| Overall Study | NOT COMPLETED | Sublingual Nitroglycerin Spray | 0 | |
| Overall Study | NOT COMPLETED | Sublingual Nitroglycerin Tablet | 0 | |
| Overall Study | NOT COMPLETED | Nitroglycerin Skin Patch | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Sublingual Nitroglycerin Spray | 0 | 66 |
| Total, all-cause mortality | Sublingual Nitroglycerin Tablet | 0 | 66 |
| Total, all-cause mortality | Nitroglycerin Skin Patch | 0 | 66 |
| Total, other adverse events | Sublingual Nitroglycerin Spray | 0 | 66 |
| Total, other adverse events | Sublingual Nitroglycerin Tablet | 0 | 66 |
| Total, other adverse events | Nitroglycerin Skin Patch | 0 | 66 |
| Total, serious adverse events | Sublingual Nitroglycerin Spray | 0 | 66 |
| Total, serious adverse events | Sublingual Nitroglycerin Tablet | 0 | 66 |
| Total, serious adverse events | Nitroglycerin Skin Patch | 0 | 66 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02961946
GET https://conductscience.org/api/trials/v1/NCT02961946/registered