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Trial · NCT02964572

Registered outcomes16

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
Primarychanges in the secretion of IL-1 beta from peripheral blood mononuclear cellsDay 60The effect of empagliflozin on the secretion of IL-1beta from peripheral blood mononuclear cells
SecondaryChanges in the secretion of TNF-alpha from peripheral blood mononuclear cells, before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of beta-hydroxybutyrate, before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in body weight (kg), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of insulin (µU/mL), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of glucagon (pg/mL), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of free fatty acid (μEq/L), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum glycated albumin (%), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of glucose (mg/dL), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of uric acid (mg/dL), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of liver enzymes (aspartate aminotransferase and alanine aminotransferase (IU/L)), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum lipids (total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol (mg/dL)), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
SecondaryChanges in serum concentrations of creatinine (mg/dL), before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
Secondary
Changes in spot urine concentrations of glucose (mg/dL) and creatinine (mg/dL) (those will be combined to report spot urine glucose-to-creatinine ratio in mg/mg), before and after the administration of empagliflozin or glimepiride
Day 60 plus or minus 32 days
SecondaryChanges in mRNA expression level (PCR, fold) of IL-1beta, TNF-alpha, and NLRP3 in peripheral blood mononuclear cells, before and after the administration of empagliflozin or glimepirideDay 60 plus or minus 32 days
Secondary
Changes in protein expression pattern (western blot, relative to control) of IL-1beta, TNF-alpha, and NLRP3 in peripheral blood mononuclear cells, before and after the administration of empagliflozin or glimepiride
Day 60 plus or minus 32 days

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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