Rehabilitative Trial for the Rescue of Neurophysiological Parameters in Progranulin Deficient Subjects
NCT02999282, Not applicable, Completed, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Rehabilitative Trial for the Rescue of Neurophysiological Parameters in Progranulin Deficient Subjects | ClinicalTrials.gov |
| NCT number | NCT02999282 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 70 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | ClinicalTrials.gov |
| Conditions | Frontotemporal Dementia, GRN Related Frontotemporal Dementia | ClinicalTrials.gov |
| Interventions | Anodal transcranial direct current stimulation, Sham transcranial direct current stimulation | ClinicalTrials.gov |
| First posted | 2016-12-21 | ClinicalTrials.gov |
| Last updated | 2020-03-03 | ClinicalTrials.gov |
Registered outcomes 18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in SICI measurements from Baseline | Baseline - 2 weeks | By using transcranial magnetic stimulation (TMS), the investigators will evaluate the effects of frontal and prefrontal anodal transcranial magnetic stimulation on short interval intracortical inhibition (SICI) | ClinicalTrials.gov |
| Primary | Change in ICF measurements from Baseline | Baseline - 2 weeks | By using transcranial magnetic stimulation (TMS), the investigators will evaluate the effects of frontal and prefrontal anodal transcranial magnetic stimulation on intracortical facilitation (ICF). | ClinicalTrials.gov |
| Secondary | Change in SICI measurements from Baseline | Baseline - 1 month - 3 months - 6 months | By using transcranial magnetic stimulation (TMS), the investigators will evaluate the effects of frontal and prefrontal anodal transcranial magnetic stimulation on short interval intracortical inhibition (SICI) | ClinicalTrials.gov |
| Secondary | Change in ICF measurements from Baseline | Baseline - 1 month - 3 months - 6 months | By using transcranial magnetic stimulation (TMS), the investigators will evaluate the effects of frontal and prefrontal anodal transcranial magnetic stimulation on intracortical facilitation (ICF). | ClinicalTrials.gov |
| Secondary | Change in LICI measurements from Baseline | Baseline - 1 month - 3 months - 6 months | By using transcranial magnetic stimulation (TMS), the investigators will evaluate the effects of frontal and prefrontal anodal transcranial magnetic stimulation on long interval intracortical inhibition (LICI). | ClinicalTrials.gov |
| Secondary | Change in SICF measurements from Baseline | Baseline - 1 month - 3 months - 6 months | By using transcranial magnetic stimulation (TMS), the investigators will evaluate the effects of frontal and prefrontal anodal transcranial magnetic stimulation on short interval intracortical facilitation (SICF). | ClinicalTrials.gov |
| Secondary | Change in MMSE scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | The Mini Mental State Examination (MMMSE) is a 30-point questionnaire that is used to measure cognitive impairment. | ClinicalTrials.gov |
| Secondary | Change in phonemic fluencies scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | Produce as many words as possible beginning with a specified letter in 60 seconds | ClinicalTrials.gov |
| Secondary | Change in semantic fluencies scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | Produce as many words as possible from a category in 60 seconds | ClinicalTrials.gov |
| Secondary | Change in digit span forward scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | Participants hear a sequence of numerical digits and are tasked to recall the sequence correctly, with increasingly longer sequences being tested in each trial. The participant's span is the longest number of sequential digits that can accurately be remembered. | ClinicalTrials.gov |
| Secondary | Change in digit span backward scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | Participants hear a sequence of numerical digits and are tasked to recall the sequence correctly in reverse order, with increasingly longer sequences being tested in each trial. The participant's span is the longest number of sequential digits that can accurately be remembered. | ClinicalTrials.gov |
| Secondary | Change in camel and cactus test scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | Evaluates associative semantic memory with 64 items presented for naming and word-picture matching. | ClinicalTrials.gov |
| Secondary | Change in TMTA scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | The task requires a subject to connect a sequence of 25 consecutive targets on a sheet of paper to examine cognitive processing speed. | ClinicalTrials.gov |
| Secondary | Change in TMTB scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | The task requires a subject to connect a sequence of 25 consecutive targets on a sheet of paper, alternating between numbers and letters, to examine executive functioning. | ClinicalTrials.gov |
| Secondary | Change in Stroop test scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | Measure a person's selective attention capacity and skills, as well as their processing speed ability. | ClinicalTrials.gov |
| Secondary | Change in Symbol Digit test scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | It consists of digit-symbol pairs followed by a list of digits. Under each digit the subject should write down the corresponding symbol as fast as possible. The number of correct symbols within the allowed time is measured. | ClinicalTrials.gov |
| Secondary | Change in Block Design test scores from Baseline | Baseline - 2 weeks - 3 months - 6 months | To evaluated spatial visualization ability and motor skills. The test-taker uses hand movements to rearrange blocks that have various color patterns on different sides to match a pattern. The items in a block design test are scored both by accuracy in matching the pattern and by speed in completing each item. | ClinicalTrials.gov |
| Secondary | Change in The modified EkmanFaces Test from Baseline | Baseline - 2 weeks - 3 months - 6 months | Each face is presented on a sheet with six labels of basic emotions below the photograph. The patient was required to respond verbally, deciding the label that best described the facial expression shown. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 3
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 6
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Block Copy Test | Secondary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Picture Matching Task | Secondary outcome | ConductCognition |
| Semantic Triads Task | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)