Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 11 of 11

List	Outcome	Time frame	Description
Primary	Plasma HIV RNA kinetics	3 months	Time to undetectable (\<20 c/mL)
Primary	Quantification of the size of the proviral HIV reservoir	1 year	Copies of total HIV-1 DNA per 10⁶ CD4+ T cells as measured by digital droplet PCR
Primary	Time to viral rebound during ATI	12 weeks	Days from stopping ART to plasma HIV RNA \>5,000 on two consecutive measurements
Secondary	Incidence of treatment emerging events (Safety and tolerability)	1 year	Frequence and severity of adverse events (AE), adverse reactions (AR), serious adverse events (SAE), serious adverse reactions (SAR) and suspected unexpected serious adverse reactions (SUSAR).
Secondary	Quantification of the intact proviral DNA	1 year	Intact HIV-1 DNA in CD4+ T cells (copies per million cells) as measured by dd-PCR.
Secondary	Quantification of HIV mRNA and/or p24 positive cells	30 days from study entry	Frequency of mRNA/p24 postive per 1 million CD4+ T cells by FISH-flow
Secondary	Immune reconstitution	1 year	Absolute CD4+ and CD8+ T cell count
Secondary	Analytic treatment interruption (ATI) study	64 weeks	Time to first plasma HIV RNA \>5000 c/mL
Secondary	Impact of pre-ART virus sensitivity to 3BNC117 on ATI outcomes	Baseline and at viral rebound	3BNC117 sensitivity determined by PhenoSense and/or HIV env sequencing
Secondary	T cell mediated HIV specific immunity	First of 365 days	T cell immunity as determined by the HIV AIM assay
Other	Plasma cytokine and immune activation biomarker levels	1 year	Soluble IL-6, sCD14, sCD163

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Twenty rows a page, as JSON. No key.

GET https://conductscience.org/api/trials/v1/NCT03041012/registered