Trial · NCT03079869

Transition to Ferric Citrate Among Hemodialysis and Peritoneal Dialysis Patients

NCT03079869, Phase 4, Completed, Kaiser Permanente; results first posted 2022-01-13

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Transition to Ferric Citrate Among Hemodialysis and Peritoneal Dialysis Patients. Trials, record NCT03079869. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03079869

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Transition to Ferric Citrate Among Hemodialysis and Peritoneal Dialysis Patients
NCT number: NCT03079869
Status: Completed
Phases: Phase 4
Enrollment: 55 participants, actual
Lead sponsor: Kaiser Permanente
Conditions: Hyperphosphatemia
Interventions: Ferric Citrate
First posted: 2017-03-15
Last updated: 2022-01-13
Results first posted: 2022-01-13

Source ClinicalTrials.gov

Registered outcomes4

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Phosphorus Levels	6 months	Serum phosphorus levels measured by mg/dL from the 6 months prior to enrollment were compared to serum phosphorus levels collected during the 6 months of ferric citrate use
Secondary	Intravenous (IV) Iron	6 months	The amount of intravenous (IV) iron in mg used per month by participants for 6 months before and 6 months on Ferric Citrate treatment.
Secondary	Erythropoiesis Stimulating Agents (ESA) Dose	6 months	Mean Erythropoiesis Stimulating Agents (ESA) use from the 6 months prior to enrollment were compared to ESA use during the 6 months of ferric citrate use. The mean ESA dose units given to each participant per month was used in the analysis of this outcome.
Secondary	Median Pill Count	6 months	median pill count of ferric citrate pills/day required to maintain phosphorus control

Source ClinicalTrials.gov

Outcomes4

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Phosphorus Levels	6 months	The final analysis included 21 Hemodialysis and 26 Peritoneal Dialysis patients after exclusion of early dropouts. Wilcoxon signed rank test was used to compare pre-treatment and on-treatment	mg/dL	MEAN
SECONDARY	Intravenous (IV) Iron	6 months	The final analysis included 21 Hemodialysis and 26 Peritoneal Dialysis patients after exclusion of early dropouts. Wilcoxon signed rank test was used to compare pre-treatment and on-treatment.	mg/mo	MEAN
SECONDARY	Erythropoiesis Stimulating Agents (ESA) Dose	6 months	The final analysis included 21 Hemodialysis and 26 Peritoneal Dialysis patients after exclusion of early dropouts. Wilcoxon signed rank test was used to compare pre-treatment and post-treatment.	units/mo	MEAN
SECONDARY	Median Pill Count	6 months	The final analysis included 21 Hemodialysis and 26 Peritoneal Dialysis patients after exclusion of early dropouts.	tablets per day	MEDIAN

Source ClinicalTrials.gov

Results by group16

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Phosphorus Levels	Ferric Citrate - Hemodialysis	Pre-treatment	5.3	Standard Deviation 1	mg/dL
Phosphorus Levels	Ferric Citrate - Peritoneal Dialysis	Pre-treatment	5.6	Standard Deviation 0.8	mg/dL
Phosphorus Levels	Ferric Citrate - Hemodialysis	On-treatment	5.4	Standard Deviation 1.1	mg/dL
Phosphorus Levels	Ferric Citrate - Peritoneal Dialysis	On-treatment	6	Standard Deviation 1.8	mg/dL
Intravenous (IV) Iron	Ferric Citrate - Hemodialysis	Pre-Treatment	249.2	Standard Deviation 215.6	mg/mo
Intravenous (IV) Iron	Ferric Citrate - Peritoneal Dialysis	Pre-Treatment	21.2	Standard Deviation 43.1	mg/mo
Intravenous (IV) Iron	Ferric Citrate - Hemodialysis	On-Treatment	102	Standard Deviation 137.5	mg/mo
Intravenous (IV) Iron	Ferric Citrate - Peritoneal Dialysis	On-Treatment	11.6	Standard Deviation 33.7	mg/mo
Erythropoiesis Stimulating Agents (ESA) Dose	Ferric Citrate - Hemodialysis	Pre-Treatment	28761.1	Standard Deviation 41314.1	units/mo
Erythropoiesis Stimulating Agents (ESA) Dose	Ferric Citrate - Peritoneal Dialysis	Pre-Treatment	16724.4	Standard Deviation 14042.3	units/mo

1 to 10 of 16Source ClinicalTrials.gov

See all 16 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Ferric Citrate - Hemodialysis	28
Overall Study	STARTED	Ferric Citrate - Peritoneal Dialysis	27
Overall Study	COMPLETED	Ferric Citrate - Hemodialysis	15
Overall Study	COMPLETED	Ferric Citrate - Peritoneal Dialysis	16
Overall Study	NOT COMPLETED	Ferric Citrate - Hemodialysis	13
Overall Study	NOT COMPLETED	Ferric Citrate - Peritoneal Dialysis	11

Source ClinicalTrials.gov

Adverse events70

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Black stool	Gastrointestinal disorders	Ferric Citrate - Hemodialysis	20	27
other	Black stool	Gastrointestinal disorders	Ferric Citrate - Peritoneal Dialysis	25	27
other	Diarrhea	Gastrointestinal disorders	Ferric Citrate - Hemodialysis	10	27
other	Diarrhea	Gastrointestinal disorders	Ferric Citrate - Peritoneal Dialysis	10	27
other	Constipation	Gastrointestinal disorders	Ferric Citrate - Hemodialysis	4	27
other	Constipation	Gastrointestinal disorders	Ferric Citrate - Peritoneal Dialysis	5	27
other	Bloating/Gas	Gastrointestinal disorders	Ferric Citrate - Hemodialysis	2	27
other	Bloating/Gas	Gastrointestinal disorders	Ferric Citrate - Peritoneal Dialysis	2	27
other	Abdominal pain	Gastrointestinal disorders	Ferric Citrate - Hemodialysis	1	27
other	Abdominal pain	Gastrointestinal disorders	Ferric Citrate - Peritoneal Dialysis	2	27

1 to 10 of 70Source ClinicalTrials.gov

See all 70 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Ferric Citrate - Hemodialysis	0	27
Total, all-cause mortality	Ferric Citrate - Peritoneal Dialysis	0	27
Total, other adverse events	Ferric Citrate - Hemodialysis	23	27
Total, other adverse events	Ferric Citrate - Peritoneal Dialysis	27	27
Total, serious adverse events	Ferric Citrate - Hemodialysis	7	27
Total, serious adverse events	Ferric Citrate - Peritoneal Dialysis	10	27

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Ferric Citrate - Hemodialysis vs Ferric Citrate - Peritoneal Dialysis: deaths from any cause	Trial comparisons
Ferric Citrate - Hemodialysis vs Ferric Citrate - Peritoneal Dialysis: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03079869

GET https://conductscience.org/api/trials/v1/NCT03079869/events?page=2

API reference For AI assistants