Trial · NCT03081416
"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
NCT03081416, Phase 3, Completed, Brooke Army Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. "THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department". Trials, record NCT03081416. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03081416
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"
- NCT number
- NCT03081416
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 80 participants, actual
- Lead sponsor
- Brooke Army Medical Center
- Conditions
- Headache, Intranasal Ketamine
- Interventions
- Ketamine, Normal saline, Metoclopramide, Ketorolac, Dexamethasone, Benadryl
- First posted
- 2017-03-16
- Last updated
- 2018-01-18
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | VAS 30 min | 30 min | Change in Visual Analogue Score at 30 minutes |
| Secondary | VAS 60 min | 60 min | Change in Visual Analogue Score at 60 minutes |
| Secondary | NRS at discharge | Discharge | Numerical Rating Scale at discharge |
| Secondary | NRS 24 hours | 24 hours | Pain NRS score at 24 hours post discharge |
| Secondary | NRS 72 Hours | 72 Hours | Pain NRS score at 72 hours post discharge |
| Secondary | Side effects | At 15 min then at 30 min intervals while in the ED | Side effects reported by patients in both treatments arms |
| Secondary | Repeat ED/primary care encounters | 24 and 72 hours | Need for repeat patient evaluation at 24-72 hours |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03081416
GET https://conductscience.org/api/trials/v1/NCT03081416/registered