Trial · NCT03112863
Comparison of the Cosmetic Effects of Bakuchiol and Retinol
NCT03112863, Early phase 1, Completed, University of California, Davis; results first posted 2021-11-02
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Comparison of the Cosmetic Effects of Bakuchiol and Retinol. Trials, record NCT03112863. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03112863
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Comparison of the Cosmetic Effects of Bakuchiol and Retinol
- NCT number
- NCT03112863
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 44 participants, actual
- Lead sponsor
- University of California, Davis
- Conditions
- Wrinkle, Photoaging
- Interventions
- Bakuchiol, Retinol
- First posted
- 2017-04-13
- Last updated
- 2021-11-02
- Results first posted
- 2021-11-02
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Wrinkle Appearance | 12 week | Assessed using image analysis based assessment of wrinkle severity (depth and length). The primary outcome measure was image-analysis-based assessment of wrinkle severity and pigmentation at 12 weeks. |
| Primary | Percentage of Participants With Change in Appearance of Skin Pigmentation | 12 week | Assessed using image analysis based assessment of facial pigment |
| Secondary | Number of Reports of Stinging, Burning, Itching | Assessed at Week 4, 8, and 12. | Subjective tolerability assessment of stinging, burning, itching. Secondary outcome measures included redness, participant-reported tolerability (itching, burning and stinging) and in-person clinical assessments (pigmentation, scaling and erythema) throughout the study. |
| Secondary | Number of Reports of Facial Erythema Assessment | week 4, week 8 and week 12 | Image analysis based assessment of facial erythema |
Source ClinicalTrials.gov
Outcomes4
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Wrinkle Appearance | 12 week | 21 participants were analyzed in the Bakuchiol group and 23 participants were analyzed in the Retinol group. | percentage of reduced fine wrinkles | NUMBER |
| PRIMARY | Percentage of Participants With Change in Appearance of Skin Pigmentation | 12 week | Pigmentation was assessed through clinical grading and through facial analysis of the surface area of involvement and overall pigment intensity. | percentage of participants | NUMBER |
| SECONDARY | Number of Reports of Stinging, Burning, Itching | Assessed at Week 4, 8, and 12. | reports | NUMBER | |
| SECONDARY | Number of Reports of Facial Erythema Assessment | week 4, week 8 and week 12 | reports | NUMBER |
Source ClinicalTrials.gov
Results by group8
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Wrinkle Appearance | Bakuchiol | 19.0 | percentage of reduced fine wrinkles | ||
| Change in Wrinkle Appearance | Retinol | 23.2 | percentage of reduced fine wrinkles | ||
| Percentage of Participants With Change in Appearance of Skin Pigmentation | Bakuchiol | 59 | percentage of participants | ||
| Percentage of Participants With Change in Appearance of Skin Pigmentation | Retinol | 44 | percentage of participants | ||
| Number of Reports of Stinging, Burning, Itching | Bakuchiol | 0 | reports | ||
| Number of Reports of Stinging, Burning, Itching | Retinol | 0 | reports | ||
| Number of Reports of Facial Erythema Assessment | Bakuchiol | 0 | reports | ||
| Number of Reports of Facial Erythema Assessment | Retinol | 0 | reports |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Bakuchiol | 21 | |
| Overall Study | STARTED | Retinol | 23 | |
| Overall Study | COMPLETED | Bakuchiol | 21 | |
| Overall Study | COMPLETED | Retinol | 23 | |
| Overall Study | NOT COMPLETED | Bakuchiol | 0 | |
| Overall Study | NOT COMPLETED | Retinol | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Bakuchiol | 0 | 0 |
| Total, all-cause mortality | Retinol | 0 | 0 |
| Total, other adverse events | Bakuchiol | 0 | 21 |
| Total, other adverse events | Retinol | 0 | 23 |
| Total, serious adverse events | Bakuchiol | 0 | 0 |
| Total, serious adverse events | Retinol | 0 | 0 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03112863
GET https://conductscience.org/api/trials/v1/NCT03112863/registered