Trial · NCT03191240
AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA
NCT03191240, Phase 2, Completed, Asan Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA. Trials, record NCT03191240. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03191240
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- AMCPR (Augmented-Medication CardioPulmonary Resuscitation) Trial for OHCA
- NCT number
- NCT03191240
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 110 participants, actual
- Lead sponsor
- Asan Medical Center
- Conditions
- Out-of-Hospital Cardiac Arrest
- Interventions
- Vasopressins, Normal saline
- First posted
- 2017-06-19
- Last updated
- 2022-03-08
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Sustained return of spontaneous circulation (ROSC) | for 20 minutes after the time that participants had a palpable pulse | CPCR result Achievement of sustained ROSC was declared when patients had a palpable pulse for more than 20 minutes. |
| Secondary | Improvement of arterial diastolic blood pressure assessed by arterial line | during CPR, every 10 seconds after arterial line insertion until the termination of CPR due to ROSC or death, whichever came first, assessed up to 30 minutes | Successful adult resuscitation is more likely when diastolic blood pressure is \> 25 to 30 mmHg. The 2015 AHA Guidelines for CPR and ECC recommend "trying to improve quality of CPR by optimizing chest compression parameters or giving vasopressors or both" if diastolic blood pressure is \<20 mmHg. Investigators will record the hemodynamic monitor in real-time. |
| Secondary | Improvement of end-tidal carbon dioxide concentrations assessed by capnography | during CPR, every one minute after endotracheal tube insertion until the termination of CPR due to ROSC or death, whichever came first, assessed up to 30 minutes | End-tidal carbon dioxide concentrations during CPR are primarily dependent on pulmonary blood flow and therefore reflect cardiac output. Failure to maintain end-tidal carbon dioxide concentrations \> 10 mmHg during adult CPR reflects poor cardiac output and strongly predicts unsuccessful resuscitation. Investigators will record the end-tidal carbon dioxide concentrations in real-time. |
| Secondary | Improvement of acid-base status measured by blood-gas analysis | during CPR, 5, 10, 15, and 20 minute after arterial line insertion and termination of CPR | Data are insufficient to make a conclusions, acid-base status can reflect the status of the ischemic insult on a cellular level. The changed of acid-base status during CPR may be associated with outcomes in cardiac arrest patients. |
| Secondary | Improvement of lactate level measured by blood-gas analysis | during CPR, 5, 10, 15, and 20 minute after arterial line insertion and termination of CPR | In previous studies, low lactate level was prognostic factors for favourable outcome after sustained ROSC. Lactate level can reflect the status of the ischemic insult on a cellular level. |
| Secondary | Low level of neuron specific enolase level | 24, 48, and 72 hours after ROSC | Low level of neuron specific enolase level is known as a prognostic indicator of neurologic outcome after cardiac arrest. |
| Secondary | Good neurological outcome based on Cerebral Performance Categories Scale | checked at hospital discharge (participants will be followed for duration of hospital stay, an expected average of 4 weeks) | CPC 1. Good cerebral performance: conscious, alert, able to work, might have mild neurologic or psychologic deficit. CPC 2. Moderate cerebral disability: conscious, sufficient cerebral function for independent activities of daily life. CPC 3. Severe cerebral disability: conscious, dependent on others for daily support because of impaired brain function. CPC 4. Coma or vegetative state: any degree of coma without the presence of all brain death criteria. CPC 5. Brain death: apnea, areflexia, EEG silence, etc. Good neurologic outcome is defined as CPC 1 and 2. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03191240
GET https://conductscience.org/api/trials/v1/NCT03191240/registered