Trial · NCT03192020
Trial Comparing Treatment Strategies in Dupuytren's Contracture
NCT03192020, Phase 4, Active not recruiting, Tampere University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Trial Comparing Treatment Strategies in Dupuytren's Contracture. Trials, record NCT03192020. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03192020
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Trial Comparing Treatment Strategies in Dupuytren's Contracture
- NCT number
- NCT03192020
- Status
- Active not recruiting
- Phases
- Phase 4
- Enrollment
- 302 participants, actual
- Lead sponsor
- Tampere University
- Conditions
- Dupuytren Contracture
- Interventions
- Percutaneous needle fasciotomy (PNF), Collagenase Clostridium Histolyticum (CCH) 2.9 MG/ML [Xiaflex], Limited fasciectomy (LF)
- First posted
- 2017-06-19
- Last updated
- 2026-04-29
Source ClinicalTrials.gov
Registered outcomes19
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Rate of success | 5 year follow-ups | Success is a composite outcome comprising of 1) at least 50% contracture release from the recruitment and 2) patient is in patient accepted symptom state (PASS). PASS is defined by question: "Would you be satisfied and not in need for any other treatment if the functional impairment caused by the contracture would remain the same as it is today for the rest of your life?". Primary time point is five years' follow-up visit. |
| Secondary | QuickDASH | 3 months, 2, 5 and 10 year follow-ups | QuickDASH questionnaire is a validated upper extremity specific questionnaire consisting of 11 tasks/questions about the functional capacity and the pain. |
| Secondary | Perceived hand function | 3 months, 2, 5 and 10 year follow-ups | Perceived hand function will be assessed pre- and postoperatively by VAS scale. |
| Secondary | Global rating | 3 months, 2, 5 and 10 year follow-ups | Global rating to treatment effect will be evaluated by question: "How would you rate the function of your hand compared to the situation before the treatment?". The options are in 5-step Likert scale from (-2) Much worse to (+2) Much better: This question is also used as anchor question in the MCII analysis in which +1 and +2 are considered to present meaningful improvement to the patient. |
| Secondary | EQ-5D-3L | 3 months, 2, 5 and 10 year follow-ups | EQ-5D-3L is a generic instrument for assessing quality of life comprising 5 dimensions and VAS for health level. |
| Secondary | Rate of Patient Accepted Symptom State | 3 months, 2, 5 and 10 year follow-ups | PASS is a relevant patient-centered outcome measurement, which reflects the overall state in which patients consider themselves as being well. It is a state of the symptoms between complete remission and subjective dissatisfaction with the symptoms. |
| Secondary | Rate of patients achieving clinically significant improvement | 10 year follow-up | Percentage of patients achieving clinically significant improvement (50% better PED) will be assessed. |
| Secondary | Rate of patients achieving full contracture release | 3 months, 2, 5 and 10 year follow-ups | Percentage of patients achieving full contracture release (PED 0°-5°) will be assessed. |
| Secondary | Willingness to undergo same treatment | 3 months and 2 year follow-ups | Patient satisfaction with the treatment will be assessed by a simple "yes" or "no" question: "Would you prefer the same treatment again, if the result would be the same as it is now?" |
| Secondary | Major adverse events | 3 months, 2, 5 and 10 year follow-ups | In the trial will be reported major adverse events, which include: tendon rupture, nerve injury, arterial injury, CRPS and infection, skin rupture or hematoma that needs hospitalization/revision surgery. |
1 to 10 of 19Source ClinicalTrials.gov
See all 19 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03192020
GET https://conductscience.org/api/trials/v1/NCT03192020/registered