Trial · NCT03199417
Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)
NCT03199417, Phase 2, Phase 3, Terminated, University of Michigan
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL). Trials, record NCT03199417. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03199417
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)
- NCT number
- NCT03199417
- Status
- Terminated
- Phases
- Phase 2, Phase 3
- Enrollment
- 50 participants, actual
- Lead sponsor
- University of Michigan
- Conditions
- Knee Osteoarthritis
- Interventions
- Multiprofen, Placebo
- First posted
- 2017-06-26
- Last updated
- 2019-03-20
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in pain visual analog scale (VAS) scores (0-10) from baseline | week 0, week 3, week 6, week 12 | Measurement of change in patient reported pain score (VAS) at various follow up appointments. The scale is from 0-10, with 10 being the most pain. |
| Secondary | Change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores from baseline | week 0, week 3, week 6, week 12 | Change in patient reported knee pain and function scores. WOMAC score has 3 subdivisions which include knee pain, stiffness, and physical function. The score ranges from 0-96, with lower scores representing better knee pain, stiffness, and function. |
| Secondary | Change in Range of motion (ROM) from baseline | week 0, week 3, week 6, week 12 | Change in range of motion of the knee at various time points that will be compared to pre-treatment range of motion. Higher range of motion is correlated with better outcome and better function. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers8
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03199417
GET https://conductscience.org/api/trials/v1/NCT03199417/registered