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Trial · NCT03223337

Results by group540

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2487818 (M4)47.2803Geometric Coefficient of Variation 67.7Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2487818 (M4)28.7930Geometric Coefficient of Variation 30.6Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2506102 (M5)16.7177Geometric Coefficient of Variation 43.9Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2506102 (M5)11.0208Geometric Coefficient of Variation 30.9Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2506104 (M3)NAGeometric Coefficient of Variation NAHour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2506104 (M3)NAGeometric Coefficient of Variation NAHour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2531398 (M6)33.8516Geometric Coefficient of Variation 49.3Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2531398 (M6)20.8451Geometric Coefficient of Variation 27.8Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Moderate Hepatic Impairment ParticipantsGSK2531401 (M13)51.9052Geometric Coefficient of Variation 34.1Hour*nanogram per milliliter
Part 1: Area Under the Concentration-time Curve From Time Zero (Pre-dose) to Last Time of Quantifiable Concentration (AUC [0-t]) of GSK1278863 and Its MetabolitesPart 1: Healthy ParticipantsGSK2531401 (M13)39.4939Geometric Coefficient of Variation 32.3Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK1278863299.5322Geometric Coefficient of Variation 39.9Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK1278863205.6322Geometric Coefficient of Variation 37.2Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2391220 (M2)91.1105Geometric Coefficient of Variation 44.9Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2391220 (M2)46.7771Geometric Coefficient of Variation 27.9Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2487818 (M4)63.4564Geometric Coefficient of Variation 40.3Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2487818 (M4)31.4750Geometric Coefficient of Variation 29.0Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2506102 (M5)19.3023Geometric Coefficient of Variation 36.8Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2506102 (M5)11.1555Geometric Coefficient of Variation 27.1Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Mild Hepatic Impairment ParticipantsGSK2506104 (M3)91.5334Geometric Coefficient of Variation 41.2Hour*nanogram per milliliter
Part 2: AUC (0-t) of GSK1278863 and Its MetabolitesPart 2: Healthy ParticipantsGSK2506104 (M3)49.7669Geometric Coefficient of Variation 29.2Hour*nanogram per milliliter

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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