Trial · NCT03223883

Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease

NCT03223883, Phase 2, Completed, Diana Jalal; results first posted 2024-10-08

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease. Trials, record NCT03223883. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03223883

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease
NCT number: NCT03223883
Status: Completed
Phases: Phase 2
Enrollment: 94 participants, actual
Lead sponsor: Diana Jalal
Conditions: Chronic Kidney Diseases, Cognitive Decline
Interventions: Curcumin, Placebo
First posted: 2017-07-21
Last updated: 2024-10-08
Results first posted: 2024-10-08

Source ClinicalTrials.gov

Registered outcomes3

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Change in Vascular Endothelial Function at 12 Months	12 months	Brachial artery flow-mediated dilation, changed in diameter in brachial artery in response to shear stress
Secondary	Large Artery Stiffness	12 months	Aortic pulse wave velocity
Secondary	Cognitive Function	12 months	NIH toolbox battery- Executive Function Age-Corrected Standard Score is reported (T-score): This score compares the score of the test-taker to those in the NIH Toolbox nationally representative normative sample at the same age, where a score of 100 indicates performance that was at the national average for the test-taking participant's age. Age-corrected standard scores were derived separately for children (ages 3-17) and adults (ages 18-85). A score of 115 or 85, for example, would indicate that the participant's performance is 1 SD above or below the national average, respectively, when compared with like-aged participants. Higher scores indicate better performance.

Source ClinicalTrials.gov

Outcomes3

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Change in Vascular Endothelial Function at 12 Months	12 months	%change	MEDIAN
SECONDARY	Large Artery Stiffness	12 months	m/s	MEAN
SECONDARY	Cognitive Function	12 months	age-adjusted T-score	MEAN

Source ClinicalTrials.gov

Results by group6

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Change in Vascular Endothelial Function at 12 Months	Curcumin	-0.1	Inter-Quartile Range -1.5 to 1.5	%change
Change in Vascular Endothelial Function at 12 Months	Placebo	-0.7	Inter-Quartile Range -2.1 to 1.1	%change
Large Artery Stiffness	Curcumin	0.28	Standard Deviation 2.4	m/s
Large Artery Stiffness	Placebo	0.36	Standard Deviation 4.2	m/s
Cognitive Function	Curcumin	2.62	Standard Deviation 9	age-adjusted T-score
Cognitive Function	Placebo	2.25	Standard Deviation 9.5	age-adjusted T-score

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Curcumin	45
Overall Study	STARTED	Placebo	43
Overall Study	COMPLETED	Curcumin	37
Overall Study	COMPLETED	Placebo	38
Overall Study	NOT COMPLETED	Curcumin	8
Overall Study	NOT COMPLETED	Placebo	5

Source ClinicalTrials.gov

Adverse events8

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Nausea	Gastrointestinal disorders	Curcumin	7	45
other	Nausea	Gastrointestinal disorders	Placebo	6	43
other	Vomiting	Gastrointestinal disorders	Curcumin	4	45
other	Vomiting	Gastrointestinal disorders	Placebo	6	43
other	Abdominal PAIN	Gastrointestinal disorders	Curcumin	6	45
other	Abdominal PAIN	Gastrointestinal disorders	Placebo	2	43
other	Dizziness	General disorders	Curcumin	10	45
other	Dizziness	General disorders	Placebo	8	43

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Curcumin	1	45
Total, all-cause mortality	Placebo	0	43
Total, other adverse events	Curcumin	27	45
Total, other adverse events	Placebo	21	43
Total, serious adverse events	Curcumin	0	45
Total, serious adverse events	Placebo	0	43

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Curcumin vs Placebo: deaths from any cause	Trial comparisons
Curcumin vs Placebo: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03223883

GET https://conductscience.org/api/trials/v1/NCT03223883/registered

API reference For AI assistants