Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment
NCT03228498, Phase 2, Completed, Azienda Ospedaliero-Universitaria Careggi
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Choline Alphoscerate-Nimodipine in Vascular Cognitive Impairment | ClinicalTrials.gov |
| NCT number | NCT03228498 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 62 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Azienda Ospedaliero-Universitaria Careggi | ClinicalTrials.gov |
| Conditions | Vascular Cognitive Impairment | ClinicalTrials.gov |
| Interventions | Choline alphoscerate, Placebo | ClinicalTrials.gov |
| First posted | 2017-07-25 | ClinicalTrials.gov |
| Last updated | 2020-01-13 | ClinicalTrials.gov |
Registered outcomes 9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Cognitive decline evaluated by the change of MoCA test score compared with Baseline | 12 months | Cognitive decline: expressed as the loss of at least 2 points on Montreal Cognitive Assessment (MoCA) test | ClinicalTrials.gov |
| Secondary | Evaluation of selective attention | 12 months | Selective attention assessed by means of Color Word Stroop Test (CWST) | ClinicalTrials.gov |
| Secondary | Evaluation of divided attention | 12 months | Divided attention assessed by means of Trail Making Test (TMT) | ClinicalTrials.gov |
| Secondary | Evaluation of maintained attention | 12 months | Maintained attention assessed by means of Symbol Digit Modalities Test (SDMT) | ClinicalTrials.gov |
| Secondary | Evaluation of memory | 12 months | Memory assessed by means of Rey Auditory-Verbal Learning Test (RAVLT) | ClinicalTrials.gov |
| Secondary | Assessment of functional status | 12 months | Functional status measured by Disability Assessment for Dementia scale (DAD) | ClinicalTrials.gov |
| Secondary | Evaluation of depressive symptoms | 12 months | Depressive symptoms assessed by means of Center for Epidemiological Studies Depression scale (CES-D) | ClinicalTrials.gov |
| Secondary | Assessment of quality of life | 12 months | Quality of life assessed by means of Stroke-Adapted Sickness Impact Profile (SA-SIP30) | ClinicalTrials.gov |
| Secondary | Assessment of drugs' safety and tolerability. | 12 months | Evaluation of drugs' side effects incidence between two groups of treatment | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 13
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 1916007 | BACKGROUND | PubMed |
| 8937788 | BACKGROUND | PubMed |
| 12849265 | BACKGROUND | PubMed |
| 15537523 | BACKGROUND | PubMed |
| 15692125 | BACKGROUND | PubMed |
| 15817019 | BACKGROUND | PubMed |
| 20610345 | BACKGROUND | PubMed |
| 22550606 | BACKGROUND | PubMed |
| 23602162 | BACKGROUND | PubMed |
| 23867200 | BACKGROUND | PubMed |
| 28476873 | BACKGROUND | PubMed |
| 31148099 | DERIVED | PubMed |
| 33855653 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)