Trial · NCT03243019
Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
NCT03243019, Phase 2, Recruiting, University Hospital, Lille
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations. Trials, record NCT03243019. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03243019
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
- NCT number
- NCT03243019
- Status
- Recruiting
- Phases
- Phase 2
- Enrollment
- 28 participants, estimated
- Lead sponsor
- University Hospital, Lille
- Conditions
- Lymphatic Malformation, Pediatric
- Interventions
- rapamycin, MRI, Rapamycin dosage
- First posted
- 2017-08-08
- Last updated
- 2026-05-22
- Other registries' IDs
- eudract:2013-002800-15
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Response rate to rapamycin | At 3 months | Volumetric assessment by MRI. A response is considered as positive if volume decrease is superior to 1/5th of the initial volume. |
| Secondary | Kinetic of rapamycin response | At 3, 6 and 12 months | MRI assessment of the volume |
| Secondary | Efficacy of rapamycin on clinical symptoms | At 3, 6 and 12 months | Clinical and fiberscopy evaluation by scoring |
| Secondary | Pediatric Quality of Life Inventory (PedsQL 4) Scales | Baseline, at 3, 6 and 12 months | Assesses health-related quality of life among children with chronic and acute diseases |
| Secondary | Biological response to rapamycin | Baseline and at 6 months | biological effect of mTOR blockage by measuring pAKT, p70S6 kinase, pMEK, and VEGF C, VEGFR3 |
| Secondary | Rapamycin side effects | Monthly during 1 years | Side effect assessment using the NCI-CTC 3.0 scale |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03243019
GET https://conductscience.org/api/trials/v1/NCT03243019/registered