Trial · NCT03243630
Effects of Flavors on Nicotine Reinforcement in Smokers
NCT03243630, Early phase 1, Completed, Yale University; results first posted 2020-11-13
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effects of Flavors on Nicotine Reinforcement in Smokers. Trials, record NCT03243630. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03243630
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of Flavors on Nicotine Reinforcement in Smokers
- NCT number
- NCT03243630
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 26 participants, actual
- Lead sponsor
- Yale University
- Conditions
- Nicotine Dependence
- Interventions
- IV nicotine, Menthol flavor, green apple, green apple and menthol
- First posted
- 2017-08-09
- Last updated
- 2020-12-03
- Results first posted
- 2020-11-13
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | up to 3 hours per test session. | The (DEQ) Drug Effects Questionnaire has eleven questions with a minimum score of 0 to a maximum score of 100. Peak values from each time points were calculated for the change in the intensity of positive subjective effects as measured with these peak values for like and want more were averaged to obtain a summary score to represent the feel "good drug effects" composite factor. Higher scores for each DEQ represent greater endorsement of that subjective effect (e.g., on the "like drug" scale a response of 90 represents greater liking than a response of 50). |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | up to 3 hours per test session. | Data was analyzed as Intention to Treat | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group36
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Menthol E-liquid | Higher Nicotine : Max_Cool | 43.18 | Standard Deviation 26.49 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Green Apple E-liquid | Higher Nicotine : Max_Cool | 26.22 | Standard Deviation 25.83 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Green Apple and Menthol E-liquid | Higher Nicotine : Max_Cool | 25.20 | Standard Deviation 21.38 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Menthol E-liquid | Higher Nicotine : Max_Like | 56.00 | Standard Deviation 28.14 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Green Apple E-liquid | Higher Nicotine : Max_Like | 53.44 | Standard Deviation 28.03 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Green Apple and Menthol E-liquid | Higher Nicotine : Max_Like | 50.80 | Standard Deviation 34.69 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Menthol E-liquid | Higher Nicotine : Max_Dislike | 24.36 | Standard Deviation 29.86 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Green Apple E-liquid | Higher Nicotine : Max_Dislike | 25.88 | Standard Deviation 31.41 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Green Apple and Menthol E-liquid | Higher Nicotine : Max_Dislike | 20.80 | Standard Deviation 27.59 | units on a scale |
| The Reinforcing Drug Effects Will be Measured With the Drug Effects Questionnaire (DEQ). | Menthol E-liquid | Higher Nicotine : Max_Craving | 41.27 | Standard Deviation 35.29 | units on a scale |
1 to 10 of 36Source ClinicalTrials.gov
See all 36 results by groupParticipant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Study Cohort | 24 | |
| Overall Study | Menthol E-liquid Saline | Study Cohort | 22 | |
| Overall Study | Menthol E-liquid Higher | Study Cohort | 22 | |
| Overall Study | Menthol E-liquid Lower | Study Cohort | 22 | |
| Overall Study | Green Apple E-liquid Saline | Study Cohort | 20 | |
| Overall Study | Green Apple E-liquid Higher | Study Cohort | 20 | |
| Overall Study | Green Apple E-liquid Lower | Study Cohort | 20 | |
| Overall Study | Green Apple and Menthol E-liquid Saline | Study Cohort | 21 | |
| Overall Study | Green Apple and Menthol E-liquid Higher | Study Cohort | 21 | |
| Overall Study | Green Apple and Menthol E-liquid Lower | Study Cohort | 21 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Menthol E-liquid | 0 | 22 |
| Total, all-cause mortality | Green Apple E-liquid | 0 | 20 |
| Total, all-cause mortality | Green Apple and Menthol E-liquid | 0 | 20 |
| Total, other adverse events | Menthol E-liquid | 0 | 22 |
| Total, other adverse events | Green Apple E-liquid | 0 | 18 |
| Total, other adverse events | Green Apple and Menthol E-liquid | 0 | 20 |
| Total, serious adverse events | Menthol E-liquid | 0 | 22 |
| Total, serious adverse events | Green Apple E-liquid | 0 | 20 |
| Total, serious adverse events | Green Apple and Menthol E-liquid | 0 | 20 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| P50DA036151 | Yale Tobacco Center of Regulatory Science | KRISHNAN-SARIN, SUCHITRA; O'MALLEY, STEPHANIE S | YALE UNIVERSITY | NATIONAL INSTITUTE ON DRUG ABUSE | 2013 to 2017 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03243630
GET https://conductscience.org/api/trials/v1/NCT03243630/results?page=2