Trial · NCT03280342
Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine
NCT03280342, Phase 2, Withdrawn, University of Minnesota
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine. Trials, record NCT03280342. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03280342
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine
- NCT number
- NCT03280342
- Status
- Withdrawn
- Phases
- Phase 2
- Enrollment
- 0 participants, actual
- Lead sponsor
- University of Minnesota
- Conditions
- Migraine, Headache
- Interventions
- IR-TPM (Topamax), XR-TPM (Trokendi XR)
- First posted
- 2017-09-12
- Last updated
- 2019-11-01
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Controlled Oral Word Association Test (COWA)-generative phonemic fluency | Baseline (Day 1) through Day 52 | The primary outcome measure is the Controlled Oral Word Association (COWA: phonemic generative fluency). COWA was chosen as the primary endpoint since in previous studies of drug-induced cognitive impairment, this measure was sensitive to the effects of topiramate (Meador et al, 2003; Marino et al, 2012; Marino et al, 2015). The primary endpoint is a change in the COWA score from baseline to each post-dose assessment |
| Secondary | Measures of semantic verbal fluency | Baseline (Day 1) through Day 52 | Change in scores from individual baseline to each post-dose assessment on measures of semantic verbal fluency (e.g., Animals) |
| Secondary | Digit Span Backward | Baseline (Day 1) through Day 52 | Change in scores from individual baseline to each post-dose assessment on measures of working memory (i.e., Digit Span Backward) |
| Secondary | Digit Symbol Modalities Test (SDMT) | Baseline (Day 1) through Day 52 | Change in scores from individual baseline to each post-dose assessment on measure of psychomotor speed |
| Secondary | Trails A & B | Baseline (Day 1) through Day 52 | Change in scores from individual baseline to each post-dose assessment on measures of executive function |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Verbal Fluency | Primary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03280342
GET https://conductscience.org/api/trials/v1/NCT03280342/registered