Trial · NCT03291002
Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC
NCT03291002, Phase 1, Unknown, CureVac
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC. Trials, record NCT03291002. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03291002
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Study of Intratumoral CV8102 in cMEL, cSCC, hnSCC, and ACC
- NCT number
- NCT03291002
- Status
- Unknown
- Phases
- Phase 1
- Enrollment
- 98 participants, actual
- Lead sponsor
- CureVac
- Conditions
- Melanoma (Skin), Squamous Cell Carcinoma of the Skin, Carcinoma, Squamous Cell of Head and Neck, Carcinoma, Adenoid Cystic
- Interventions
- CV8102, CV8102 + anti-PD-1 therapy
- First posted
- 2017-09-25
- Last updated
- 2021-11-04
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Dose determination for dose escalation cohorts | 2 weeks | * Maximum tolerated dose (MTD) and recommended dose (RD), respectively, for CV8102 alone * MTD and recommended combination dose (RCD) for CV8102 in combination with the standard dose of an anti-PD-1 antagonist |
| Primary | Incidence of treatment related (Serious) Adverse Events (Tolerability and Safety profile) | up to 12 months (end of study) | • Tolerability and safety profile of CV8102 alone and in combination with anti-PD-1 antagonists |
| Secondary | Tumor response | up to 12 months (end of study) | • Anti-tumor activity of CV8102 per irRECIST and RECIST 1.1 |
| Secondary | Disease status | 6 months | • Tumor Assessment |
| Secondary | Tumor response | up to 12 months (end of study) | • Extent of tumor response at injected and non-injected lesions, if applicable |
| Secondary | Survival | up to 12 months (end of study) | • Survival time |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03291002
GET https://conductscience.org/api/trials/v1/NCT03291002/registered