Trial · NCT03313297
Glucocorticoids and Skin Healing in Diabetes (GC-SHealD)
NCT03313297, Phase 2, Completed, University of Leeds
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Glucocorticoids and Skin Healing in Diabetes (GC-SHealD). Trials, record NCT03313297. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03313297
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Glucocorticoids and Skin Healing in Diabetes (GC-SHealD)
- NCT number
- NCT03313297
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 28 participants, actual
- Lead sponsor
- University of Leeds
- Conditions
- Diabetes Mellitus, Type 2
- Interventions
- AZD4017, Placebo
- First posted
- 2017-10-18
- Last updated
- 2019-03-22
Source ClinicalTrials.gov
Registered outcomes18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Skin 11β-HSD1 activity | Change between day 0 and day 28 | Enzyme activity radioassay to evaluate AZD4107 efficacy in skin |
| Secondary | Urinary cortisol / cortisone metabolites | Change between day 0 and day 35 | Urine samples for tetrahydrocortisol / tetrahydrocortisone metabolite ratios to evaluate systemic AZD4107 efficacy |
| Secondary | AZD4017 in plasma | Change between day 0 and day 28 | Quantification of AZD4017 concentration in plasma to evaluate systemic AZD4107 exposure |
| Secondary | AZD4017 in skin | Change between day 0 and day 28 | Quantification of AZD4017 concentration in plasma to evaluate skin AZD4107 exposure |
| Secondary | Discontinuation due to Adverse Event | Day 42 | Adverse Event-related participant withdrawals to evaluate safety |
| Secondary | Body mass index | Change between day 0 and day 35 | Body mass index to evaluate safety |
| Secondary | Waist-hip ratio | Change between day 0 and day 35 | Waist-hip ratio to evaluate safety |
| Secondary | Blood pressure (sphygmomanometer) | Change between day 0 and day 35 | Blood pressure to evaluate safety |
| Secondary | Sudomotor function | Change between day 0 and day 35 | Conducted with a Sudoscan device to measure c-fiber innervation in hands and feet for skin function |
| Secondary | Skin hydration | Change between day 0 and day 35 | Conducted with a Corneometer device to measure skin water content for skin function |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03313297
GET https://conductscience.org/api/trials/v1/NCT03313297/registered