Trial · NCT03332225
A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis
NCT03332225, Phase 2, Completed, Hellenic Institute for the Study of Sepsis
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis. Trials, record NCT03332225. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03332225
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Trial of Validation and Restoration of Immune Dysfunction in Severe Infections and Sepsis
- NCT number
- NCT03332225
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 36 participants, actual
- Lead sponsor
- Hellenic Institute for the Study of Sepsis
- Conditions
- Sepsis, Macrophage Activation Syndrome
- Interventions
- Anakinra, Recombinant human interferon-gamma, Placebo
- First posted
- 2017-11-06
- Last updated
- 2020-07-29
- Other registries' IDs
- eudract:2017-002171-26
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Mortality | 28 days | Mortality will be compared between the groups of treatment |
| Secondary | Mortality | 90 days | Mortality will be compared between the groups of treatment |
| Secondary | Time to decrease of SOFA score by more than 50% | 28 days | The time to decrease of SOFA score by more than 50% will be compared between the groups of treatment |
| Secondary | Time to infection resolution | 28 days | The time to infection resolution will be compared between the groups of treatment |
| Secondary | Duration of hospitalisation | 28 days | The duration of hospitalisation will be compared between the groups of treatment |
| Secondary | Number of secondary infections | 28 days | The number of secondary infections will be compared between the groups of treatment |
| Secondary | Cytokine stimulation | 4 days | Cytokine stimulation from peripheral blood mononuclear cells will be compared between the groups of treatment |
| Secondary | Cytokine stimulation | 7 days | Cytokine stimulation from peripheral blood mononuclear cells will be compared between the groups of treatment |
| Secondary | Gene expression | 7 days | Gene expression of peripheral blood mononuclear cells will be compared between the groups of treatment |
| Secondary | Gut microbiome changes | 7 days | Gut microbiome changes will be compared between the groups of treatment |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers15
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03332225
GET https://conductscience.org/api/trials/v1/NCT03332225/registered