Trial · NCT03359213
A Study of JR-141 in Patients With Mucopolysaccharidosis II (BR21)
NCT03359213, Phase 2, Completed, JCR Pharmaceuticals Co., Ltd.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of JR-141 in Patients With Mucopolysaccharidosis II (BR21). Trials, record NCT03359213. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03359213
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of JR-141 in Patients With Mucopolysaccharidosis II (BR21)
- NCT number
- NCT03359213
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 18 participants, actual
- Lead sponsor
- JCR Pharmaceuticals Co., Ltd.
- Conditions
- Mucopolysaccharidosis II
- Interventions
- JR-141, JR-141, JR-141
- First posted
- 2017-12-02
- Last updated
- 2025-07-24
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of participants with Adverse Events | 26 weeks | * Adverse events * Antidrug antibodies * Blood pressures in mmHg * Heart rate in beats/minute * Respiratory rate in breaths/minute * Temperature in °C * Presence or absence of abnormalities for physical examination * Presence or absence of abnormalities for 12-lead electrocardiogram * Routine laboratory tests in blood (hematology, liver function, renal function, iron-related levels) and urine (urinalysis) |
| Secondary | Plasma Pharmacokinetic parameter [Maximum Plasma Concentration [Cmax]] | 21 hours after dosing at the first and last infusions | Plasma concentration of JR-141 |
| Secondary | Plasma Pharmacokinetic parameter [Area Under the Curve [AUC]] | 21 hours after dosing at the first and last infusions | Plasma concentration of JR-141 |
| Secondary | Liver and spleen volumes (MRI) | 26 weeks | |
| Secondary | Left ventricular mass by a standard 2-dimensional Doppler echocardiogram | 26 weeks | |
| Secondary | Urinary heparan sulfate concentrations | 26 weeks | |
| Secondary | Urinary dermatan sulfate concentrations | 26 weeks | |
| Secondary | Serum heparan sulfate concentrations | 26 weeks | |
| Secondary | Serum dermatan sulfate concentrations | 26 weeks |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03359213
GET https://conductscience.org/api/trials/v1/NCT03359213/registered