Trial · NCT03374306
Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate
NCT03374306, Not applicable, Completed, The Hong Kong Polytechnic University; results first posted 2024-10-16
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate. Trials, record NCT03374306. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03374306
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Topical Application of Low-concentration (0.01%) Atropine on the Human Eye With Fast and Slow Myopia Progression Rate
- NCT number
- NCT03374306
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 71 participants, actual
- Lead sponsor
- The Hong Kong Polytechnic University
- Conditions
- Myopia
- Interventions
- Atropine (0.01%), Artificial tear
- First posted
- 2017-12-15
- Last updated
- 2024-10-16
- Results first posted
- 2024-10-16
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Annualized Changes in Refractive Error (SER) | 18 months | Annualized changes in refractive error (SER) after receiving the 0.01 atropine or artificial tears up to 18 months |
| Secondary | Annualized Change in Axial Length | 18 months | Annualized change in axial length after receiving the 0.01 atropine or artificial tears up to 18 months |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Annualized Changes in Refractive Error (SER) | 18 months | Annualized changes in refractive error (SER) | Dioptre/year | MEAN |
| SECONDARY | Annualized Change in Axial Length | 18 months | annualized change in axial length | mm/year | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Annualized Changes in Refractive Error (SER) | Atropine 0.01% | -0.70 | Standard Deviation 0.39 | Dioptre/year | |
| Annualized Changes in Refractive Error (SER) | Artifical Tear | -0.66 | Standard Deviation 0.41 | Dioptre/year | |
| Annualized Change in Axial Length | Atropine 0.01% | 0.3 | Standard Deviation 0.22 | mm/year | |
| Annualized Change in Axial Length | Artifical Tear | 0.32 | Standard Deviation 0.16 | mm/year |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Atropine 0.01% | 36 | |
| Overall Study | STARTED | Artifical Tear | 35 | |
| Overall Study | COMPLETED | Atropine 0.01% | 34 | |
| Overall Study | COMPLETED | Artifical Tear | 27 | |
| Overall Study | NOT COMPLETED | Atropine 0.01% | 2 | |
| Overall Study | NOT COMPLETED | Artifical Tear | 8 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Atropine 0.01% | 0 | 34 |
| Total, all-cause mortality | Artifical Tear | 0 | 27 |
| Total, other adverse events | Atropine 0.01% | 0 | 34 |
| Total, other adverse events | Artifical Tear | 0 | 27 |
| Total, serious adverse events | Atropine 0.01% | 0 | 34 |
| Total, serious adverse events | Artifical Tear | 0 | 27 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Atropine 0.01% vs Artifical Tear: deaths from any cause | Trial comparisons |
| Atropine 0.01% vs Artifical Tear: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03374306
GET https://conductscience.org/api/trials/v1/NCT03374306/registered