Trial · NCT03375671
Rapid Agitation Control With Ketamine in the Emergency Department
NCT03375671, Phase 2, Completed, David Barbic
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Rapid Agitation Control With Ketamine in the Emergency Department. Trials, record NCT03375671. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03375671
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Rapid Agitation Control With Ketamine in the Emergency Department
- NCT number
- NCT03375671
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 81 participants, actual
- Lead sponsor
- David Barbic
- Conditions
- Violent Aggressive Behavior, Ketamine
- Interventions
- Ketalar, Midazolam injection, Haloperidol
- First posted
- 2017-12-18
- Last updated
- 2020-11-30
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Time from first IM medication administration to adequate sedation which is defined as RASS less than or equal to -1. | 1 day | Measured using Richmond Agitation Sedation Scale (RASS) in each arm |
| Secondary | Percentage participants with adverse events in each arm | up to 4 days | measured by AE collection in each arm |
| Secondary | Percentage of participants in each arm requiring rescue medications between 5 and 30 minutes (at 5 minutes interval) after study medication(s) administration by count. | 1 day | measured by rescue medication administration |
| Secondary | Percentage of participants in each arm experiencing sedation outcomes as defined by the TROOPS criteria | 1 day | measured using Tracking and Reporting Outcomes of Procedural Sedation (TROOPS) criteria |
| Secondary | Percentage of participants with neuroleptic malignant syndrome events within 24 hours of enrollment of each arm. | 1 day | measured by occurrence of neuroleptic malignant syndrome |
| Secondary | Percentage of participants experiencing pre-hospital use of force by police in this participant population, by number and type of restraint. | 1 day | measured by police account at study enrollment |
| Secondary | Participant experience survey outcomes. | 1 day | measured using Participant Experience Survey |
| Secondary | Study Nurse Experience survey outcomes. | 1 day | measured using Study Nurse Experience Survey |
| Secondary | Effectiveness of Blinding survey outcomes | 1 day | measured using Effectiveness of Study Drug Blinding Survey |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 30477544 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03375671
GET https://conductscience.org/api/trials/v1/NCT03375671/registered