Trial · NCT03443063
Results by group110
Each measurement the trial posted, group by group, in the words and numbers it posted.
1 to 20 of 110
Download this page as JSON| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Maximum Observed Plasma Concentration (Cmax) of Lemborexant | Lemborexant: Severe Renal Impairment | 48.9 | Geometric Coefficient of Variation 41.0 | nanogram per milliliter (ng/mL) | |
| Maximum Observed Plasma Concentration (Cmax) of Lemborexant | Lemborexant: Normal Renal Function | 46.6 | Geometric Coefficient of Variation 29.2 | nanogram per milliliter (ng/mL) | |
| Area Under the Plasma Concentration-Time Curve From Time Zero to 72 Hours Post Dose (AUC[0-72h]) of Lemborexant | Lemborexant: Severe Renal Impairment | 419 | Geometric Coefficient of Variation 21.9 | hour*nanogram per milliliter (h*ng/mL) | |
| Area Under the Plasma Concentration-Time Curve From Time Zero to 72 Hours Post Dose (AUC[0-72h]) of Lemborexant | Lemborexant: Normal Renal Function | 315 | Geometric Coefficient of Variation 27.4 | hour*nanogram per milliliter (h*ng/mL) | |
| Area Under the Plasma Concentration-Time Curve From Time Zero to the Time of the Last Quantifiable Concentration (AUC[0-t]) of Lemborexant | Lemborexant: Severe Renal Impairment | 660 | Geometric Coefficient of Variation 29.3 | h*ng/mL | |
| Area Under the Plasma Concentration-Time Curve From Time Zero to the Time of the Last Quantifiable Concentration (AUC[0-t]) of Lemborexant | Lemborexant: Normal Renal Function | 439 | Geometric Coefficient of Variation 36.9 | h*ng/mL | |
| Area Under the Plasma Concentration-Time Curve Extrapolated to Infinity (AUC[0-inf]) of Lemborexant | Lemborexant: Severe Renal Impairment | 672 | Geometric Coefficient of Variation 19.6 | h*ng/mL | |
| Area Under the Plasma Concentration-Time Curve Extrapolated to Infinity (AUC[0-inf]) of Lemborexant | Lemborexant: Normal Renal Function | 449 | Geometric Coefficient of Variation 38.3 | h*ng/mL | |
| Maximum Observed Plasma Concentration (Cmax) of Metabolites of Lemborexant (M4, M9, and M10) | Lemborexant: Severe Renal Impairment | Metabolite M4 | 6.37 | Geometric Coefficient of Variation 44.8 | ng/mL |
| Maximum Observed Plasma Concentration (Cmax) of Metabolites of Lemborexant (M4, M9, and M10) | Lemborexant: Normal Renal Function | Metabolite M4 | 7.96 | Geometric Coefficient of Variation 39.5 | ng/mL |
| Maximum Observed Plasma Concentration (Cmax) of Metabolites of Lemborexant (M4, M9, and M10) | Lemborexant: Severe Renal Impairment | Metabolite M9 | 3.77 | Geometric Coefficient of Variation 44.1 | ng/mL |
| Maximum Observed Plasma Concentration (Cmax) of Metabolites of Lemborexant (M4, M9, and M10) | Lemborexant: Normal Renal Function | Metabolite M9 | 4.74 | Geometric Coefficient of Variation 45.9 | ng/mL |
| Maximum Observed Plasma Concentration (Cmax) of Metabolites of Lemborexant (M4, M9, and M10) | Lemborexant: Severe Renal Impairment | Metabolite M10 | 2.78 | Geometric Coefficient of Variation 50.5 | ng/mL |
| Maximum Observed Plasma Concentration (Cmax) of Metabolites of Lemborexant (M4, M9, and M10) | Lemborexant: Normal Renal Function | Metabolite M10 | 3.83 | Geometric Coefficient of Variation 48.0 | ng/mL |
| Time to Reach Maximum Plasma Concentration (Tmax) of Lemborexant and Its Metabolites (M4, M9, and M10) | Lemborexant: Severe Renal Impairment | Lemborexant | 1.00 | Full Range 0.50 to 3.00 | hour (h) |
| Time to Reach Maximum Plasma Concentration (Tmax) of Lemborexant and Its Metabolites (M4, M9, and M10) | Lemborexant: Normal Renal Function | Lemborexant | 1.00 | Full Range 1.00 to 1.50 | hour (h) |
| Time to Reach Maximum Plasma Concentration (Tmax) of Lemborexant and Its Metabolites (M4, M9, and M10) | Lemborexant: Severe Renal Impairment | Metabolite M4 | 3.50 | Full Range 1.00 to 4.00 | hour (h) |
| Time to Reach Maximum Plasma Concentration (Tmax) of Lemborexant and Its Metabolites (M4, M9, and M10) | Lemborexant: Normal Renal Function | Metabolite M4 | 2.00 | Full Range 1.00 to 4.00 | hour (h) |
| Time to Reach Maximum Plasma Concentration (Tmax) of Lemborexant and Its Metabolites (M4, M9, and M10) | Lemborexant: Severe Renal Impairment | Metabolite M9 | 1.00 | Full Range 1.00 to 4.00 | hour (h) |
| Time to Reach Maximum Plasma Concentration (Tmax) of Lemborexant and Its Metabolites (M4, M9, and M10) | Lemborexant: Normal Renal Function | Metabolite M9 | 1.25 | Full Range 1.00 to 2.00 | hour (h) |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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