Trial · NCT03446456
Vasopressin and Pain Perception in the Brain
NCT03446456, Phase 1, Phase 2, Recruiting, University of Maryland, Baltimore; results first posted 2021-12-16
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Vasopressin and Pain Perception in the Brain. Trials, record NCT03446456. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03446456
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Vasopressin and Pain Perception in the Brain
- NCT number
- NCT03446456
- Status
- Recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 56 participants, estimated
- Lead sponsor
- University of Maryland, Baltimore
- Conditions
- Acute Pain
- Interventions
- Arginine vasopressin, Saline, Observational learning, fMRI data aquisition
- First posted
- 2018-02-26
- Last updated
- 2026-10-28
- Results first posted
- 2021-12-16
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation | Day 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds | Blood oxygenation level dependent (BOLD) responses will allow the identification of relative activation/deactivation in the brain as a result of events (e.g. painful stimulations) that will be given during the experiment. Changes in the Percentage of BOLD signal are calculated as the BOLD signal in the right supplementary motor area during the 20-second heat pain divided by the whole-brain average BOLD signal during that 20-second heat pain. |
| Secondary | Heating Temperature | Day 1 (calibration) | On Day 1, the heating temperature was calibrated to the individual level. The heating temperature corresponding to 50 out of 100 visual analog scale pain ratings was selected as the testing temperature for day 2 (test). |
| Secondary | Pain Ratings | Day 2 (test) | Participants will provide their pain on a Visual Analogue Scale raging from 0=no pain to 100= maximum unbearable pain. Normal value will be absence of pain. |
| Other | Implicit Association Test (IAT) Response Latency Difference | Day 1 | The IAT is a behavioral test that examines racial biases via measuring the strength of associations between concepts (e.g., African-American, Asian, White) and evaluations (good, bad). Participants were asked to press a response key when they saw images (people) or words (good/bad) on the screen. Response latencies (RL) were measured in milliseconds using E-prime as the reaction time to press the response key. An RL difference (D) score was calculated as 1) Compute the standard deviation (SD) of RL from overall trials; 2) M1 is the mean of RL in the condition where "White" and "good" share the same response key. M2 is the mean of RL in the condition where "African-American/Asian people" and "good" share the same response key; 3) D = (M2-M1)/SD. The D score ranges from -2 to +2. Positive values indicate a racial preference for White people. Negative values indicate a racial preference for African-American/Black or Asian people. A value close to 0 indicates no racial preference. |
Source ClinicalTrials.gov
Outcomes4
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation | Day 2, the average of 24 trials of painful stimulations with each stimulation lasting 20 seconds | percentage of BOLD signal change | MEAN | |
| SECONDARY | Heating Temperature | Day 1 (calibration) | celsius degree | MEAN | |
| OTHER_PRE_SPECIFIED | Implicit Association Test (IAT) Response Latency Difference | Day 1 | difference score | MEAN | |
| SECONDARY | Pain Ratings | Day 2 (test) | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group8
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation | Saline | 0.485 | Standard Deviation 0.271 | percentage of BOLD signal change | |
| Change in BOLD Singal in Supplementary Motor Area Compared to Whole Brain Average During the Painful Stimulation | Arginine Vasopressin | 0.482 | Standard Deviation 0.387 | percentage of BOLD signal change | |
| Heating Temperature | Saline | 44.16 | Standard Deviation 0.77 | celsius degree | |
| Heating Temperature | Arginine Vasopressin | 44.44 | Standard Deviation 0.83 | celsius degree | |
| Implicit Association Test (IAT) Response Latency Difference | Saline | 0.03 | Standard Deviation 0.37 | difference score | |
| Implicit Association Test (IAT) Response Latency Difference | Arginine Vasopressin | 0.07 | Standard Deviation 0.32 | difference score | |
| Pain Ratings | Saline | 44.84 | Standard Deviation 24.49 | units on a scale | |
| Pain Ratings | Arginine Vasopressin | 47.19 | Standard Deviation 26.27 | units on a scale |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Saline | 20 | |
| Overall Study | STARTED | Arginine Vasopressin | 20 | |
| Overall Study | COMPLETED | Saline | 16 | |
| Overall Study | COMPLETED | Arginine Vasopressin | 16 | |
| Overall Study | NOT COMPLETED | Saline | 4 | |
| Overall Study | NOT COMPLETED | Arginine Vasopressin | 4 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Saline | 0 | 16 |
| Total, all-cause mortality | Arginine Vasopressin | 0 | 16 |
| Total, other adverse events | Saline | 0 | 16 |
| Total, other adverse events | Arginine Vasopressin | 0 | 16 |
| Total, serious adverse events | Saline | 0 | 16 |
| Total, serious adverse events | Arginine Vasopressin | 0 | 16 |
Source ClinicalTrials.gov
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Saline vs Arginine Vasopressin: deaths from any cause | Trial comparisons |
| Saline vs Arginine Vasopressin: serious adverse events | Trial comparisons |
Tests1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as |
|---|---|
| Implicit Association Test (IAT) | Other outcome |
Source ConductCognition
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03446456
GET https://conductscience.org/api/trials/v1/NCT03446456/registered