Trial · NCT03449251
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
NCT03449251, Phase 2, Active not recruiting, Cambridge University Hospitals NHS Foundation Trust
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin. Trials, record NCT03449251. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03449251
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin
- NCT number
- NCT03449251
- Status
- Active not recruiting
- Phases
- Phase 2
- Enrollment
- 170 participants, estimated
- Lead sponsor
- Cambridge University Hospitals NHS Foundation Trust
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes Mellitus
- Interventions
- Apelin, Relaxin, Normal saline, Verapamil, LN Monomethyl arginine
- First posted
- 2018-02-28
- Last updated
- 2026-09-30
Source ClinicalTrials.gov
Registered outcomes58
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Sub-study 1a: Changes in markers of glucose homeostasis in healthy participants after infusion of apelin (Glucose) | Visit 2 to visit 4, over a period of up to 8 weeks | Glucose, in mmol/l |
| Primary | Sub-study 1a: Changes in markers of glucose homeostasis in healthy participants after infusion of apelin (C-Peptide) | Visit 2 to visit 4, over a period of up to 8 weeks | C-peptide, in pmol/L |
| Primary | Sub-study 1a: Changes in markers of glucose homeostasis in healthy participants after infusion of apelin (Glucagon) | Visit 2 to visit 4, over a period of up to 8 weeks | Glucagon, in pg/ml |
| Primary | Sub-study 1a: Changes in markers of glucose homeostasis in healthy participants after infusion of apelin (Insulin) | Visit 2 to visit 4, over a period of up to 8 weeks | Insulin, in pmol/L |
| Primary | Sub-study 1a: Changes in markers of glucose homeostasis in healthy participants after infusion of apelin (TNF-alpha) | Visit 2 to visit 4, over a period of up to 8 weeks | TNF-alpha, in pg/ml |
| Primary | Sub-study 1b: Changes in markers of glucose homeostasis in participants with increased weight and participants with type 2 diabetes mellitus after infusion of apelin with or without mixed meal tolerance in obese/overweight and T2DM participants | Visit 2 to visit 5, over a period of up to 14 weeks | Glucose, in mmol/l |
| Primary | Sub-study 1b: Changes in markers of glucose homeostasis in participants with increased weight and participants with type 2 diabetes mellitus after infusion of apelin with or without mixed meal tolerance in obese/overweight and T2DM participants | Visit 2 to visit 5, over a period of up to 14 weeks | C-peptide, in pmol/L |
| Primary | Sub-study 1b: Changes in markers of glucose homeostasis in participants with increased weight and participants with type 2 diabetes mellitus after infusion of apelin with or without mixed meal tolerance in obese/overweight and T2DM participants | Visit 2 to visit 5, over a period of up to 14 weeks | Glucagon, in pg/ml |
| Primary | Sub-study 1b: Changes in markers of glucose homeostasis in participants with increased weight and participants with type 2 diabetes mellitus after infusion of apelin with or without mixed meal tolerance in obese/overweight and T2DM participants | Visit 2 to visit 5, over a period of up to 14 weeks | Insulin, in pmol/L |
| Primary | Sub-study 1b: Changes in markers of glucose homeostasis in participants with increased weight and participants with type 2 diabetes mellitus after infusion of apelin with or without mixed meal tolerance in obese/overweight and T2DM participants | Visit 2 to visit 5, over a period of up to 14 weeks | TNF-alpha, in pg/ml |
1 to 10 of 58Source ClinicalTrials.gov
See all 58 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03449251
GET https://conductscience.org/api/trials/v1/NCT03449251/registered?page=2