Trial · NCT03474263
IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)
NCT03474263, Phase 2, Withdrawn, Implicit Bioscience
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS). Trials, record NCT03474263. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03474263
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)
- NCT number
- NCT03474263
- Status
- Withdrawn
- Phases
- Phase 2
- Enrollment
- 0 participants, actual
- Lead sponsor
- Implicit Bioscience
- Conditions
- Amyotrophic Lateral Sclerosis
- Interventions
- Biologic: IC14 (monoclonal antibody against human CD14)
- First posted
- 2018-03-22
- Last updated
- 2026-05-05
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Glial Activation | one month | Glial activation measured in the motor region measured by \[11C\]-PBR28 positron emission tomography (PET). Studies have shown this marker localizes to areas of glial activation and correlates with disease progression and outcomes. |
| Primary | Serum neurofilament | one month | Serum neurofilament is a biomarker that has been shown to correlate with ALS severity |
| Primary | Urinary p75 neurotrophin receptor | one month | Urinary p75 neurotrophin receptor is a biomarker that has been shown to correlate with ALS severity |
| Secondary | Incidence of Treatment-Emergent Adverse Events (Safety, Tolerability) | six weeks | Adverse event reporting |
| Secondary | Immunogenicity | six weeks | Human anti-monoclonal antibodies |
| Secondary | Peak Plasma Concentration of IC14 | one month | Peak Plasma Concentration (Cmax) of IC14 |
| Secondary | Pharmacodynamics | one month | Monocyte CD14 saturation |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03474263
GET https://conductscience.org/api/trials/v1/NCT03474263/registered