Trial · NCT03558516

Magnesium and Intraoperative Blood Loss in Meningioma Surgery

NCT03558516, Phase 3, Completed, Mahidol University; results first posted 2020-07-13

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Magnesium and Intraoperative Blood Loss in Meningioma Surgery. Trials, record NCT03558516. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03558516

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Magnesium and Intraoperative Blood Loss in Meningioma Surgery
NCT number: NCT03558516
Status: Completed
Phases: Phase 3
Enrollment: 80 participants, actual
Lead sponsor: Mahidol University
Conditions: Meningioma
Interventions: Magnesium group, Normal saline group
First posted: 2018-06-15
Last updated: 2020-07-13
Results first posted: 2020-07-13

Source ClinicalTrials.gov

Registered outcomes7

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Intraoperative Blood Loss	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.	We measure the amount of blood loss in the operative room in suction box, gauze and plastic bag. The unit measure is millimeter.
Secondary	Intraoperative Packed Red Cell (PRC) Transfusion	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.	The amount of blood transfusion in patient who required PRC transfusion intraoperatively.
Secondary	Postoperative MOCA Score	Postoperative day 3-7	MOCA or Montreal Cognitive Assessment is a screening instrument used to facilitate the assessment of cognitive impairment. MOCA scores range between 0-30, do higher values represent a better outcome. A score of 26 or over is considered to be normal. We measure Montreal assessment score for assess cognitive function after operation at postoperative day 3-7.
Secondary	Sevoflurane Requirement	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.	Amount of sevoflurane agents usage during surgery. The unit of measurement of volatile agent is minimum alveolar concentration (MAC). 1 MAC-hour was defined as 2% of sevoflurane for 1 hour duration.
Secondary	Fentanyl Requirement	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.	Amount of fentanyl usage during surgery
Secondary	Cis-atracurium Requirement	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.	Amount of cis-atracurium usage during surgery
Secondary	Patient Received Intraoperative Packed Red Cell (PRC)	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.	Number of patients who required Intraoperative PRC transfusion

Source ClinicalTrials.gov

Outcomes7

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Intraoperative Blood Loss	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.		ml	MEDIAN
SECONDARY	Intraoperative Packed Red Cell (PRC) Transfusion	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.		unit of packed red cell	MEDIAN
SECONDARY	Postoperative MOCA Score	Postoperative day 3-7	There are some missing data due to patient's visual, hearing or writing problems that occurred postoperatively.	score on the MOCA scale	MEDIAN
SECONDARY	Sevoflurane Requirement	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.		average minimum alveolar concentration	MEAN
SECONDARY	Fentanyl Requirement	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.		mcg/kg/hr	MEAN
SECONDARY	Cis-atracurium Requirement	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.		mg/kg/hr	MEAN
SECONDARY	Patient Received Intraoperative Packed Red Cell (PRC)	Intraoperative period from skin was incised to the skin was closure, an average 5 hours.		Participants	COUNT_OF_PARTICIPANTS

Source ClinicalTrials.gov

Results by group14

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Intraoperative Blood Loss	Group NSS	510	Full Range 100 to 1600	ml
Intraoperative Blood Loss	Group Mg	500	Full Range 70 to 2300	ml
Intraoperative Packed Red Cell (PRC) Transfusion	Group NSS	2	Full Range 1 to 4	unit of packed red cell
Intraoperative Packed Red Cell (PRC) Transfusion	Group Mg	1	Full Range 1 to 3	unit of packed red cell
Postoperative MOCA Score	Group NSS	23	Full Range 15 to 28	score on the MOCA scale
Postoperative MOCA Score	Group Mg	25	Full Range 8 to 30	score on the MOCA scale
Sevoflurane Requirement	Group NSS	0.65	Standard Error 0.12	average minimum alveolar concentration
Sevoflurane Requirement	Group Mg	0.66	Standard Error 0.17	average minimum alveolar concentration
Fentanyl Requirement	Group NSS	0.65	Standard Error 0.19	mcg/kg/hr
Fentanyl Requirement	Group Mg	0.6	Standard Error 0.18	mcg/kg/hr

1 to 10 of 14Source ClinicalTrials.gov

See all 14 results by group

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Group NSS	40
Overall Study	STARTED	Group Mg	40
Overall Study	COMPLETED	Group NSS	38
Overall Study	COMPLETED	Group Mg	38
Overall Study	NOT COMPLETED	Group NSS	2
Overall Study	NOT COMPLETED	Group Mg	2

Source ClinicalTrials.gov

Adverse events6

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Minor neurological complication	Nervous system disorders	Group NSS	10	38
other	Minor neurological complication	Nervous system disorders	Group Mg	12	38
other	Infection	Infections and infestations	Group NSS	7	38
other	Infection	Infections and infestations	Group Mg	1	38
serious	Severe brain edema	Nervous system disorders	Group NSS	1	38	1
serious	Severe brain edema	Nervous system disorders	Group Mg	1	38	1

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Group NSS	0	38
Total, all-cause mortality	Group Mg	0	38
Total, other adverse events	Group NSS	17	38
Total, other adverse events	Group Mg	13	38
Total, serious adverse events	Group NSS	1	38
Total, serious adverse events	Group Mg	1	38

Source ClinicalTrials.gov

Papers17

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
16670112	BACKGROUND	PubMed
19199498	BACKGROUND	PubMed
20821343	BACKGROUND	PubMed
21364460	BACKGROUND	PubMed
23562933	BACKGROUND	PubMed
24105697	BACKGROUND	PubMed
24137015	BACKGROUND	PubMed
24649414	BACKGROUND	PubMed
25824556	BACKGROUND	PubMed
27123421	BACKGROUND	PubMed

1 to 10 of 17

See all 17 papers

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons3

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Group NSS vs Group Mg: Patient Received Intraoperative Packed Red Cell (PRC)	Trial comparisons
Group NSS vs Group Mg: deaths from any cause	Trial comparisons
Group NSS vs Group Mg: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT03558516

GET https://conductscience.org/api/trials/v1/NCT03558516/registered

API reference For AI assistants