Trial · NCT03575676
Efficacy and Safety of SOM3355 in Huntington's Disease Chorea
NCT03575676, Phase 2, Completed, SOM Innovation Biotech SA
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy and Safety of SOM3355 in Huntington's Disease Chorea. Trials, record NCT03575676. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03575676
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy and Safety of SOM3355 in Huntington's Disease Chorea
- NCT number
- NCT03575676
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 32 participants, actual
- Lead sponsor
- SOM Innovation Biotech SA
- Conditions
- Huntington's Chorea
- Interventions
- SOM3355 100mg BID, SOM3355 200mg BID, Placebo BID
- First posted
- 2018-07-02
- Last updated
- 2019-09-16
- Other registries' IDs
- eudract:2018-000203-16
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | UHDRS (Unified Huntington's Disease Rating Scale) Total Maximal Chorea (TMC) score | 6 months | UHDRS subscore used to measure the effectiveness of SOM3355 on HD chorea. |
| Secondary | Clinical Global Impression of Change (CGIC) scale | 6 months | PGIC reflects clinician's belief about the efficacy of treatment. |
| Secondary | Patient Global Impression of Change (PGIC) scale | 6 months | PGIC reflects a patient's belief about the efficacy of treatment. |
| Secondary | UHDRS Total Functional Capacity (TFC) | 6 months | A standardized rating scale used to assess capacity to work, handle finances, perform domestic chores and self-care tasks. |
| Secondary | UHDRS Functional Assessment | 6 months | Functional Assessment should be judged according to the investigator's opinion of capacity to perform the activity rather than the actual performance of this activity. |
| Secondary | UHDRS Gait score | 6 months | UHDRS subscore used to assess patient's gait. |
| Secondary | UHDRS Total Motor Score (TMS) | 6 months | Categoric clinical rating scale assessing multiple domains of motor disability in HD. |
| Secondary | Columbia Suicide Severity Rating Scale (C-SSRS) | 6 months | International validated questionnaire used for suicide assessment. |
| Secondary | Safety (number of participants with adverse events) | 6 months | The maximum grade for each type of AE will be recorded for each subject, and frequency tables will be presented and reviewed to determine patterns. The relationship of the AE to the study treatment will be taken into consideration. Hypotension and cardiovascular events will be specifically analyzed. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 36494329 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03575676
GET https://conductscience.org/api/trials/v1/NCT03575676/registered