Trial · NCT03638622
Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancer Cancer.
NCT03638622, Phase 1, Phase 2, Completed, Massachusetts General Hospital; results first posted 2021-02-21
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancer Cancer. Trials, record NCT03638622. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT03638622
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancer Cancer.
- NCT number
- NCT03638622
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 30 participants, actual
- Lead sponsor
- Massachusetts General Hospital
- Conditions
- Oral Cancer
- Interventions
- Photodynamic Therapy
- First posted
- 2018-08-20
- Last updated
- 2021-02-21
- Results first posted
- 2021-02-21
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants With no Residual Tumor Following Photodynamic Therapy (PDT) | Up to 2 years | Histologically confirmed the absence of residual disease at follow-up lesion site biopsy (7 days) and from additional clinical examinations during follow-up visits. The follow-up visits happened approximately once every 3 months after treatment until Institutional Review Board (IRB) approval (October 12, 2020). |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Participants With no Residual Tumor Following Photodynamic Therapy (PDT) | Up to 2 years | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group1
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Participants With no Residual Tumor Following Photodynamic Therapy (PDT) | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 22 | Participants |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 30 | |
| Overall Study | COMPLETED | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 29 | |
| Overall Study | NOT COMPLETED | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 1 |
Source ClinicalTrials.gov
Adverse events5
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Discomfort during light treatment | General disorders | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 2 | 30 | |
| other | Difficulty in holding PDT applicator in patient mouth | General disorders | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 2 | 30 | |
| other | Hypotensive after light treatment (PDT treatment day) | General disorders | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 1 | 30 | |
| other | Nausea and vomiting after light treatment | General disorders | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 4 | 30 | |
| other | Mild headache after light treatment | General disorders | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 1 | 30 |
Source ClinicalTrials.gov
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 0 | 30 |
| Total, other adverse events | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 10 | 30 |
| Total, serious adverse events | Aminolevulinic Acid (ALA) Photodynamic Therapy (PDT) | 0 | 30 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 35367616 | DERIVED |
Source PubMed
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| UH3CA189901 | Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral | HASAN, TAYYABA; CELLI, JONATHAN P | MASSACHUSETTS GENERAL HOSPITAL | NATIONAL CANCER INSTITUTE | 2016 to 2019 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT03638622
GET https://conductscience.org/api/trials/v1/NCT03638622/registered